Results 121 to 130 of about 5,426,024 (302)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Deep Learning for Karolinska Sleepiness Scale Classification Based On Eye Aspect Ratio with SMOTE-Enhanced Data Balancing

Jurnal Nasional Pendidikan Teknik Informatika (JANAPATI)
This paper addresses the challenge of accurately classifying sleepiness levels based on the Karolinska Sleepiness Scale (KSS) using Eye Aspect Ratio (EAR) data, especially when class imbalance leads to biased predictions.
Ahmad Zaini, Eko Mulyanto Yuniarno, Yoyon K Suprapto, Annida Miftakhul Farodisa   +3 more
doaj   +1 more source

Cosmological Bounds on Spatial Variations of Physical Constants

, 2005
We derive strong observational limits on any possible large-scale spatial variation in the values of physical 'constants' whose space-time evolution is driven by a scalar field.
B. E. J. Pagel, J. Darling, J. D. Barrow, J. D. Barrow, J. D. Barrow, J. W. Moffat, John D. Barrow, K. A. Olive, R. Petitjean   +8 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

A Ratio Scale Metric and the Compatibility of Ratio Scales: On the Possibility of Arrow's Impossibility Theorem 

Proceedings of the International Symposium on the Analytic Hierarchy Process, 1994
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

RATIO-SCALE ELICITATION OF DEGREES OF BELIEF [PDF]

, 1988
Most research on rule-based inference under uncertainty has focused on the normative validity and efficiency of various belief-update algorithms. In this paper we shift the attention to the inputs of these algorithms, namely, to the degrees of beliefs ...
Schocken, Shimon
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Unveiling global flood hotspots: Optimized machine learning techniques for enhanced flood susceptibility modeling

Journal of Hydrology: Regional Studies
Study region: Worldwide Study focus: Floods are among the most catastrophic and dangerous natural calamities globally, causing irreparable damage to human lives and property, and environmental degradation. Flood susceptibility mapping is a cost-effective
Mahdi Panahi, Khabat Khosravi, Fatemeh Rezaie, Zahra Kalantari, Jeong-A. Lee   +4 more
doaj   +1 more source