Results 91 to 100 of about 15,576,713 (334)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Revised global vertically integrated remanent magnetization model of the oceanic lithosphere with comparison to LCS-1 model and MSS-1 magnetic measurements

Earth and Planetary Physics
The lithospheric magnetic field is an important component of the geomagnetic field, and the oceanic lithosphere exhibits distinct characteristics. Because of its formation mechanisms, evolutionary history, and geomagnetic field polarity reversals, the ...
ShiDa Sun, Hui Li, JinSong Du, Pan Zhang, Chao Chen, PengFei Liu   +5 more
doaj   +1 more source

Coseismic Rupture Geometry and Slip Rupture Process During the 2018 Mw 7.1 Anchorage, South‐Central Alaska Earthquake: Intraplate Normal Faulting by Slab Tear Constrained by Geodetic and Teleseismic Data

Earth and Space Science, 2020
The Mw 7.1 Anchorage earthquake on 30 November 2018 beneath the south‐central Alaska is a rare intermediate‐depth event larger than Mw 7 that occurred in a complex subduction region, where the young Yakutat oceanic terrane wedges in the continental ...
Ping He, Yangmao Wen, Yunguo Chen, Caijun Xu, Kaihua Ding   +4 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Host-Parasite Coevolution in Continuous Space Leads to Variation in Local Adaptation across Spatial Scales [PDF]

, 2023
Bob Week, Gideon S. Bradburd
openalex   +1 more source

The warping of extra spaces accelerates the expansion of the universe

, 2010
Generic cosmological models derived from higher dimensional theories with warped extra dimensions have a nonzero cosmological constant-like term induced on the 3+1 space-time, or a physical 3-brane.
Neupane, Ishwaree P
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Land Quality, Development and Space: Does Scale Matter?

European Spatial Research and Policy, 2013
This study analyzes empirically the relationship between land quality decline and the spatial distribution of per capita income observed in Italy at different spatial scales and geographical divisions.
Luca Salvati
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Shape recognition using orientational and morphological scale‐spaces of curvatures

IET Computer Vision, 2015
In this study, a scale‐invariant representation for closed planar curves (silhouettes) is proposed. The orientations of all points within the Gaussian scale‐space of the curve are extracted.
Erdem Akagündüz
doaj   +1 more source