Results 91 to 100 of about 15,282,041 (334)
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source
Earth and Planetary PhysicsThe lithospheric magnetic field is an important component of the geomagnetic field, and the oceanic lithosphere exhibits distinct characteristics. Because of its formation mechanisms, evolutionary history, and geomagnetic field polarity reversals, the ...
ShiDa Sun +5 more
doaj +1 more source
GenEvA (I): A new framework for event generation
, 2008 We show how many contemporary issues in event generation can be recast in terms of partonic calculations with a matching scale. This framework is called GenEvA, and a key ingredient is a new notion of phase space which avoids the problem of phase space ...
Bauer, Christian W. +2 more
core +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Land Quality, Development and Space: Does Scale Matter?
European Spatial Research and Policy, 2013 This study analyzes empirically the relationship between land quality decline and the spatial distribution of per capita income observed in Italy at different spatial scales and geographical divisions.
Luca Salvati
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Shape recognition using orientational and morphological scale‐spaces of curvatures
IET Computer Vision, 2015 In this study, a scale‐invariant representation for closed planar curves (silhouettes) is proposed. The orientations of all points within the Gaussian scale‐space of the curve are extracted.
Erdem Akagündüz
doaj +1 more source
Molecular Oncology, EarlyView.Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Earth and Planetary PhysicsBy combining data from the Challenging Minisatellite Payload (CHAMP), Swarm-A, and newest Macau Science Satellite-1 (MSS-1) missions, we constructed a lithospheric magnetic field model up to spherical harmonic degree N = 100.
JiaXuan Zhang +5 more
doaj +1 more source