Results 41 to 50 of about 984,019 (267)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Free-space-coupled wavelength-scale disk resonators

Nanophotonics, 2022
Optical microresonators with low quality factor (Q$Q$) can be efficiently excited by and scatter freely propagating optical waves, but those with high Q$Q$ typically cannot.
Mirzapourbeinekalaye Babak, Samudrala Sarath, Mansouree Mahdad, McClung Andrew, Arbabi Amir   +4 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Research on Leak Detection of Low-Pressure Gas Pipelines in Buildings Based on Improved Variational Mode Decomposition and Robust Kalman Filtering

Sensors
Aiming at the complex characteristics of negative pressure waves in low-pressure pipelines inside of buildings, we proposed an estimation method of pressure fluctuation trends based on the robust Kalman filter and the improved VMD, which can be used for ...
Wenfeng Lin, Xinghao Tian
doaj   +1 more source

Scale Development for Environmental Perception of Public Space

Frontiers in Psychology, 2020
We developed a psychometric scale for measuring the subjective environmental perception of public spaces. In the scale development process, we started with an initial pool of 85 items identified from the literature that were related to environmental ...
Robbie Ho, Wing Tung Au
doaj   +1 more source

Conceptual Design and Demonstration of Space Scale for Measuring Mass in Microgravity Environment [PDF]

Journal of Astronomy and Space Sciences, 2015
In this study, a new idea for developing a space scale for measuring mass in a microgravity environment was proposed by using the inertial force properties of an object to measure its mass.
Youn-Kyu Kim, Joo-Hee Lee, Gi-Hyuk Choi, Ik-Hyeon Choi   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Improvement of Harris Algorithm Based on Gaussian Scale Space [PDF]

Engineering and Technology Journal, 2019
Features is the description of the image contents which could be corner, blob or edge. Corners are one of the most important feature to describe image, therefore there are many algorithms to detect corners such as Harris, FAST, SUSAN, etc.
Abdul Amir Karim, Rafal Sameer
doaj   +1 more source