Results 71 to 80 of about 3,018,546 (285)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Investigating the Psychometric Properties of the Emotion Regulation Flexibility Questionnaire in the Italian Context

European Journal of Investigation in Health, Psychology and Education
Background: Following the idea that individuals engage with different strategies to regulate their emotional experiences, scholars in the field of psychology have shown increasing interest in the notion of emotion regulation flexibility.
Giada Mignolli, Daiana Colledani, Francesco Tommasi, Anna Maria Meneghini   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Revisiting Psychological Contract Measurement: Validation of the PSYCONES Questionnaire

Social Sciences
The psychological contract is a fundamental construct for understanding the relationships established between employee and employer. However, the current literature states that there is no validated instrument to measure this construct.
Adrián García-Selva, Beatriz Martín-del-Rio, José Ramos-López   +2 more
doaj   +1 more source

Establishing macroecological trait datasets: digitalization, extrapolation, and validation of diet preferences in terrestrial mammals worldwide [PDF]

, 2014
Ecological trait data are essential for understanding the broad-scale distribution of biodiversity and its response to global change. For animals, diet represents a fundamental aspect of species’ evolutionary adaptations, ecological and functional roles,
Dalby, Lars, Fløjgaard, Camilla, Kissling, Wilm Daniel, Lenoir, Jonathan, Sandel, Brody, Sandom, Christopher, Svenning, Jens-Christian, Trøjelsgaard, Kristian   +7 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

The Short Form Cultural Intelligence Scale (SFCQ) A German Validation

Psychological Test Adaptation and Development
: Managing intercultural encounters is a key success factor in multicultural communities. The construct of cultural intelligence has been developed to examine individuals’ capabilities to effectively deal with cultural heterogeneity.
Dogus Darici, Julia Zimmermann, Kathrin Jonkmann   +2 more
doaj   +1 more source

Internet gaming disorder as a formative construct : implications for conceptualization and measurement [PDF]

, 2017
Background. Some people have serious problems controlling their internet and video game use. The DSM-5 now includes a proposal for ‘Internet Gaming Disorder’ as a condition in need of further study. Various studies aim to validate the proposed diagnostic
Billieux, Joël, Van Looy, Jan, van Rooij, Tony   +2 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Hindi version of the lower extremity functional scale: a study of translation, validation and cross-cultural adaptation

Revista Pesquisa em Fisioterapia
BACKGROUND: Lower Extremity Function Scale (LEFS) serves as a patient-reported outcome measure, used to evaluate the functional status of lower extremity in different musculoskeletal conditions.
Yashleen Kaur Sandhu, Nidhi Sharma, Alisha Jaiswal, Simranjeet Kaur   +3 more
doaj   +1 more source