Results 141 to 150 of about 1,959,895 (299)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Two Scales, One Methodology - Expenditure Based Equivalence Scales for the United States and Germany [PDF]

Choosing an appropriate equivalence scale is a prerequisite for comparisons of economic wellbeing income distribution, inequality or poverty. This is true for country specific work or for cross-national comparisons.
Joachim Merz, Jürgen Faik, Timothy M. Smeeding, David Johnson, Thesia Garner   +4 more
core  

Scales Fine Arts Center, Wake Forest University

, 1980
Aerial view of Scales Fine Arts ...
McNabb Studio
core   +1 more source

The Journée Nationale des Paralysés and the French Poster Child (or Why I Started Doing Research on Ebay)

Journal of the Western Society for French History
Rebecca Scales
doaj   +2 more sources

Comparison of four unidimensional pain scales and women's preferences during the first stage of labor: a cross-sectional study. [PDF]

BMC Pregnancy Childbirth
Çerçer Z, Aslan F.
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Equipercentile Equating of Scores From Common Patient-Reported Outcome Measures of Role, Social, and Emotional Functioning in Patients With Cancer. [PDF]

Psychooncology
Rothmund-Grenier M, Pilz JM, Schlosser L, Arraras JI, Groenvold M, Holzner B, Van Leeuwen M, Petersen MA, Schmidt H, Young T, Rose M, Cella D, Giesinger JM, EORTC Quality of Life Group.   +13 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Masmali and Rolando Scales in Distinct Brachycephalic Dogs: Healthy or Unhealthy Tears? [PDF]

Vet Ophthalmol
da Silva PHS, Castanheira ITF, Campos LRS, Galera PD.   +3 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source