Results 121 to 130 of about 1,637,196 (313)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Two Scales, One Methodology - Expenditure Based Equivalence Scales for the United States and Germany [PDF]

Choosing an appropriate equivalence scale is a prerequisite for comparisons of economic wellbeing income distribution, inequality or poverty. This is true for country specific work or for cross-national comparisons.
Joachim Merz, Jürgen Faik, Timothy M. Smeeding, David Johnson, Thesia Garner   +4 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Equivalence Scales Declining with Expenditure: Evidence and Implications for Income Distribution [PDF]

We estimate expenditure dependent equivalence scales for Italian couples with and without children. Following Donaldson and Pendakur (2006) we incorporate the generalized absolute equivalence-scale exactness (GAESE) restrictions into a translated ...
Fabrizio Balli, Silvia Tiezzi
core  

Associação das sub-escalas de Braden com o risco do desenvolvimento de úlcera por pressão

Revista Gaúcha de Enfermagem
Úlceras por pressão (UP) podem aumentar a incidência de complicações hospitalares, devendo-se prevenir este dano. A Escala de Braden destaca-se como instrumento para avaliar o risco de UP. O estudo objetivou identificar quais alterações, na pontuação das
Bruna Pochmann Zambonato, Michelli Cristina Silva de Assis, Mariur Gomes Beghetto   +2 more
doaj  

Notas sobre a versão em língua portuguesa da Escala de Bem-Estar Espiritual Notes on the Portuguese-language version of the Spiritual Well-Being Scale

Jornal Brasileiro de Psiquiatria, 2013
OBJETIVO: Testar a Escala de Bem-Estar Espiritual (EBE), a versão em português da Spiritual Well-Being Scale (SWB), em uma amostra de universitários matriculados em cursos de pós-graduação da área da saúde, avaliando suas qualidades psicométricas.
Edson Zangiacomi Martinez, Rodrigo Guimarães dos Santos Almeida, Fabiana Rodrigues Garcia, Antonio Carlos Duarte de Carvalho   +3 more
doaj  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Relative Inequality and Poverty in Germany and the United States Using Alternative Equivalence Scales [PDF]

German and United States data from the Luxembourg Income Study are used to compare the relative economic well-being of Germans and Americans in the 1980s.
Richard V. Burkhauser, Joachim Merz, Timothy M. Smeeding   +2 more
core   +4 more sources

Geography and scales: the place of the concepts of cartographic scale, spatial scale and geographical scale

, 2021
Para demonstrar o lugar dos conceitos das escalas cartográfica, espacial e geográfica, e entender sua influência e os sentidos que lhes são atribuídos, apresentam-se contribuições oriundas de uma pesquisa bibliométrica. A metodologia consistiu em pesquisa bibliográfica exploratória de artigos e livros, em bases digitais disponíveis no Google Scholar e ...
Oliveira, Ivanilton José, de Araújo Romão, Patrícia   +1 more
openaire   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source