Results 101 to 110 of about 1,959,895 (299)
Journal of Pain Research, 2020 Hanna Popowicz,1 Katarzyna Kwiecień-Jaguś,2 Jolanta Olszewska,1 Wioletta A Mędrzycka-Dąbrowska2 1Department of Obstetric and Gynaecological Nursing, Medical University of Gdansk, Gdansk, Poland; 2Department of Anaesthesiology Nursing and Intensive Care ...
Popowicz H +3 more
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Estimating Equivalence Scales for Tax and Benefits Systems [PDF]
When comparing, say, the welfare derived from income by a family that is comprised of two adults and three children to that of a single adult, it is necessary to take into consideration the relative needs of the respective households.
John Muellbauer, Justin van de Ven
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Journal of Industrial Design and Engineering Graphics, 2019 In the steps preceding the dimensioning and printing of a technical drawing for construction, a series of settings must be made which, if not done correctly, make that the printed drawing and the elements represented in that drawing not comply with the ...
Andrei Slonovschi, Liviu Pruna
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FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Interview with James H. Scales - OH 055
, 1978 IN PROCESSING A discussion of Scales life and work as a secret service agent for President Harry S. Truman. This interview focuses on Mr.
Scales, James H.
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Adaptação da Escala de Silhuetas Brasileiras para uso digital
Jornal Brasileiro de PsiquiatriaRESUMO Objetivo Adaptar a escala de silhuetas originais em cartões de papel e validar para uso digital. Métodos Participaram dessa pesquisa 88 jovens, os quais foram avaliados quanto ao índice de massa corporal (IMC) e questões sobre a imagem ...
Simone Cardoso Freire, Mauro Fisberg
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