Results 51 to 60 of about 2,196,235 (269)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The Arms Trade Treaty Opens New Possibilities at the UN

open access: yesCadmus, 2013
On 2 April, 2013, the Arms Trade Treaty, which had been blocked for ten years in the consensus-bound Conference on Disarmament in Geneva, was put directly before the United Nations General Assembly, and was passed by a massive majority.
John Scales Avery
doaj  

Convergently Emergent: Ecological and Enactive Approaches to the Texture of Agency

open access: yesFrontiers in Psychology, 2020
Enactive and ecological approaches to cognitive science both claim a “mutuality” between agents and their environments – that they have a complementary nature and should be addressed as a single whole system.
Marek McGann
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Entropy and Economics

open access: yesCadmus, 2012
In this essay, human society is regarded as a “superorganism”, analogous to colonies of social insects. The digestive system of the human superorganism is the global economy, which ingests both free energy and resources, and later excretes them in a ...
John Scales Avery
doaj  

A Review of Survey Instruments and Pharmacy Student Outcomes for Stress, Burnout, Depression and Anxiety

open access: yesPharmacy
While the need to measure burnout, stress and mental health among pharmacy students has been emphasized in the literature, there is limited information on which validated scales should be used.
Kelly C. Lee   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Description et interprétation des écailles de truites de mer (Salmo trutta L.) de deux rivières de Basse-Normandie : l'Orne et la Touques

open access: yesKnowledge and Management of Aquatic Ecosystems, 1990
Les écailles de plus de 10.000 adultes de truites de mer capturés principalement par piégeage à la remontée sur l'Orne et la Touques (Basse-Normandie) ont été examinées.
RICHARD A., BAGLINIERE J. L.
doaj   +1 more source

Morfologia externa de espécimes adultos de Paratanaisia bragai (Santos, 1934) (Digenea: Eucotylidae) External morphology of the adults specimens of Paratanaisia bragai (Santos, 1934)(Diginea; Eucotylidae)

open access: yesRevista Brasileira de Parasitologia Veterinária, 2007
Espécimes adultos de Paratanaisia bragai foram coletados de ductos renais de Columba livia infectados naturalmente, fixados em glutaraldeído 2,5% e processados para microscopia eletrônica de varredura. Foram identificados dois tipos distintos de escamas,
Solange V.P.B. Brandolini   +1 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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