Results 131 to 140 of about 3,449,394 (355)

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Why the Crackling Deformations of Single Crystals, Metallic Glasses, Rock, Granular Materials, and the Earth's Crust Are So Surprisingly Similar

open access: yesFrontiers in Physics, 2019
Recent experiments show that the deformation properties of a wide range of solid materials are surprisingly similar. When slowly pushed, they deform via intermittent slips, similar to earthquakes.
Karin A. Dahmen   +3 more
doaj   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

open access: yesFEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt   +4 more
wiley   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

open access: yesFEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche   +2 more
wiley   +1 more source

A coiled‐coil domain triggers oligomerization of MmpL10, the mycobacterial transporter of trehalose polyphleate precursor

open access: yesFEBS Letters, EarlyView.
Most MmpLs transport lipids and glycolipids of the complex mycomembrane of mycobacteria. This study shows that MmpL10 from Mycobacterium smegmatis, the transporter of the trehalose polyphosphate precursor, harbors a coiled‐coil‐like extension. Biochemical and electron microscopy studies demonstrate that the coiled‐coil enables MmpL10 to trimerize.
Julie Couston   +7 more
wiley   +1 more source

Scaling in biology [PDF]

open access: yesCurrent Biology, 2009
Ernest Rutherford is credited with the provocative assertion that all attempts to expand human knowledge are either physics or stamp collecting. Whatever your opinion of this statement, the two modes are not mutually exclusive, and some of the most interesting efforts to marry the two endeavours have looked at questions of scale in biology.
openaire   +3 more sources

A Toolkit Modeling Approach for Sustainable Forest Management Planning: Achieving Balance between Science and Local Needs

open access: yesEcology and Society, 2007
To assist forest managers in balancing an increasing diversity of resource objectives, we developed a toolkit modeling approach for sustainable forest management (SFM). The approach inserts a meta-modeling strategy into a collaborative modeling framework
Brian R. Sturtevant   +8 more
doaj   +1 more source

Dynamic scaling at classical phase transitions approached through non-equilibrium quenching

open access: yes, 2014
We use Monte Carlo simulations to demonstrate generic scaling aspects of classical phase transitions approached through a quench (or annealing) protocol where the temperature changes as a function of time with velocity $v$.
Liu, Cheng-Wei   +2 more
core   +1 more source

Evolutionary interplay between viruses and R‐loops

open access: yesFEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi   +4 more
wiley   +1 more source

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