Results 171 to 180 of about 9,460,007 (367)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Large-scale identification of ubiquitination sites by mass spectrometry
, 2013 Namrata D. Udeshi +3 more
openalex +2 more sources
Printing strategies for scaling-up perovskite solar cells [PDF]
, 2021 Yulong Wang +6 more
openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Underwater Image Enhancement Based on Global and Local Equalization of Histogram and Dual-Image Multi-Scale Fusion [PDF]
, 2020 Linfeng Bai +3 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Apical constriction drives tissue-scale hydrodynamic flow to mediate cell elongation
, 2014 Bing He +3 more
openalex +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Unifying Optimization Algorithms to Aid Software System Users: optimx for R
Journal of Statistical Software, 2011 R users can often solve optimization tasks easily using the tools in the optim function in the stats package provided by default on R installations. However, there are many other optimization and nonlinear modelling tools in R or in easily installed add ...
John C. Nash, Ravi Varadhan
doaj
Population-based validation of a German version of the Brief Resilience Scale
, 2018 Andrea Chmitorz +11 more
openalex +2 more sources