Results 71 to 80 of about 415,563 (249)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation

eLife
Homeostatic plasticity represents a set of mechanisms that are thought to recover some aspect of neural function. One such mechanism called AMPAergic scaling was thought to be a likely candidate to homeostatically control spiking activity.
Carlos Gonzalez-Islas, Zahraa Sabra, Ming-fai Fong, Pernille Yilmam, Nicholas Au Yong, Kathrin Engisch, Peter Wenner   +6 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Large Time Behavior of Solutions to the Nonlinear Heat Equation with Absorption with Highly Singular Antisymmetric Initial Values

Advanced Nonlinear Studies, 2020
In this paper, we study global well-posedness and long-time asymptotic behavior of solutions to the nonlinear heat equation with absorption, ut-Δ⁢u+|u|α⁢u=0{u_{t}-\Delta u+\lvert u\rvert^{\alpha}u=0}, where u=u⁢(t,x)∈ℝ{u=u(t,x)\in\mathbb{R}}, (t,x)∈(0,∞)×
Mouajria Hattab, Tayachi Slim, Weissler Fred B.   +2 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

A Toolkit Modeling Approach for Sustainable Forest Management Planning: Achieving Balance between Science and Local Needs

Ecology and Society, 2007
To assist forest managers in balancing an increasing diversity of resource objectives, we developed a toolkit modeling approach for sustainable forest management (SFM). The approach inserts a meta-modeling strategy into a collaborative modeling framework
Brian R. Sturtevant, Andrew Fall, Daniel D. Kneeshaw, Neal P. P. Simon, Michael J. Papaik, Kati Berninger, Frédérik Doyon, Don G. Morgan, Christian Messier   +8 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Revisiting the Lee-Yang singularities in the four-dimensional Ising model: a tribute to the memory of Ralph Kenna

Condensed Matter Physics
We have studied numerically the Lee-Yang singularities of the four dimensional Ising model at criticality, which is believed to be in the same universality class as the φ44 scalar field theory.
J. J. Ruiz-Lorenzo
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source