Results 81 to 90 of about 415,563 (249)
Universal properties of branched copolymers in dilute solutions
Condensed Matter PhysicsWe analyze the universal conformational properties of complex copolymer macromolecules, based on two topologies: the rosette structure containing fc linear branches and fr closed loops grafted to the central core, and the symmetric pom-pom structure ...
K. Haydukivska, V. Blavatska
doaj +1 more source
Comment on ‘High-income does not protect against hurricane losses’
Environmental Research Letters, 2017 Geiger et al ( Environ. Res. Lett. 2016 11 084012) employ two functional relationships to characterize hurricane damage in the USA—either based on GDP (one exponent) or on per capita GDP and population (two exponents).
Diego Rybski +2 more
doaj +1 more source
Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome
Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja +8 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Establishing usable innovations
Frontiers in Health ServicesThe persistence of the science to service gap is evidence that evidence is not enough when defining evidence-based programs. Innovations must be developed with attention to the internal and external validity of the innovations themselves so that ...
Dean L. Fixsen +2 more
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Predictive modeling of permeability loss at high-barium formation using symbolic regression
International Journal of Applied Mechanics and EngineeringMineral scaling is a common issue in oil recovery, causing severe formation damage and reduced permeability. This primarily results from chemical incompatibility between the injected and formation brines, which induces the precipitation of salts such as ...
Saifi Redha +4 more
doaj +1 more source