Results 51 to 60 of about 286,236 (217)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Vanishing moments for scaling vectors
International Journal of Mathematics and Mathematical Sciences, 2004 One advantage of scaling vectors over a single scaling function is the compatibility of symmetry and orthogonality. This paper investigates the relationship between symmetry, vanishing moments, orthogonality, and support length for a scaling vector Φ ...
David K. Ruch
doaj +1 more source
Weakest-Link Scaling and Extreme Events in Finite-Sized Systems
Entropy, 2015 Weakest-link scaling is used in the reliability analysis of complex systems. It is characterized by the extensivity of the hazard function instead of the entropy.
Dionissios T. Hristopulos +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Complexity and scaling in quantum quench in 1 + 1 dimensional fermionic field theories
Journal of High Energy Physics, 2019 We consider the scaling behavior of circuit complexity under quantum quench in an a relativistic fermion field theory on a one dimensional spatial lattice.
Sinong Liu
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Scaling of Lagrangian structure functions
Physical Review ResearchWe use stochastic closure theory and generalized Green-Kubo relations to show that the velocity structure functions have two distinct scaling regimes connected by a passover. Initially, after a brief ballistic (Batchelor) scaling, the structure functions
Björn Birnir, Luiza Angheluta
doaj +1 more source