Results 41 to 50 of about 13,195 (290)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Communications Earth & EnvironmentPegmatites of the lithium-cesium-tantalum type are widely dismissed as potential scandium hosts. Here we show that beryl from the Bailongshan pegmatite deposit in northwest China contains anomalously high scandium, with scandium oxide reaching up to 1.85
Tao Hong +8 more
doaj +1 more source
Concentration and Separation of Scandium from Ni Laterite Ore Processing Streams
Metals, 2017 The presence of a considerable amount of scandium in lateritic nickel-cobalt ores necessitates the investigation of possible processing alternatives to recover scandium as a byproduct during nickel and cobalt production.
Şerif Kaya +3 more
doaj +1 more source
Separations, 2023 Scandium, a valuable element with restricted production sources mainly situated in China and Russia, is typically obtained as a by-product during the production of various materials.
Aikaterini Toli +4 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Synthesis of an Arenide-Masked Scandium Complex Accom-panied by Reductively Induced C-H Activation [PDF]
, 2022 Reduction of 3N-supported ScCl(ketguan)(NImDipp) (ScCl) with K(C10H8) generates the naphthalenide-masked species [(18-c-6)K(μ-η6:η4-C10H8)Sc(ketguan)(NImDipp)] (Scnaph) and cyclometallated [K(18-c-6)(Et2O)][Sc{(DippN)[2-iPr-6-(CMe2)C6H3N]C(NCHtBu2 ...
Skye, Fortier +2 more
core +2 more sources
Metals, 2022 Scandium metal has generated a lot of interest during the past years. This is due to the various crucial applications it has found ground in and the lack of production in countries outside China and Russia. Apart from rare earth ores, scandium is present
Eleni Mikeli +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
, 2019 The precise control of regio- and stereochemistry in the cyclopolymerization of heteroatom-functionalized α,ω-dienes is of much interest and importance, but has remained a challenge to date.
Yi Luo +13 more
core +1 more source