Results 31 to 40 of about 840,881 (357)
Scanning force microscopy of chromatin. [PDF]
Scanning microscopy, 1995 Scanning force microscopy (SFM) is a new method to obtain the topography of surfaces with nanometer-resolution. The ability to image under liquids makes the technique attractive for biological applications, especially for the determination of the ultrastructure of biomolecules under native conditions.
Fritzsche, Wolfgang +2 more
openaire +1 more source
Cardiovascular Diabetology, 2013 Red blood cells (RBCs) are highly deformable and possess a robust membrane that can withstand shear force. Previous research showed that in diabetic patients, there is a changed RBC ultrastructure, where these cells are elongated and twist around ...
A. Buys +5 more
semanticscholar +1 more source
Bidirectional quantitative force gradient microscopy
New Journal of Physics, 2015 Dynamic operation modes of scanning force microscopy based on probe resonance frequency detection are very successful methods to study force-related properties of surfaces with high spatial resolution.
Christopher F Reiche +5 more
doaj +1 more source
Fast Scanning Probe Microscopy via Machine Learning: Non-Rectangular Scans with Compressed Sensing and Gaussian Process Optimization. [PDF]
Small, 2020 Fast scanning probe microscopy enabled via machine learning allows for a broad range of nanoscale, temporally resolved physics to be uncovered. However, such examples for functional imaging are few in number.
K. Kelley +7 more
semanticscholar +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Exposing hidden periodic orbits in scanning force microscopy
Communications PhysicsThe nonlinear interaction between the tip of a scanning probe microscope (SPM) and a sample is manifested in the emergence of bifurcations and unstable branches in the frequency response of a driven cantilever.
Lukas Böttcher +6 more
doaj +1 more source
Nanotechnology Reviews, 2017 Nanomedicine has achieved a huge success in delivering a wide variety of drug molecules into the target site of the body. In this respect, the characterization of nanoformulation is very important to investigate the drug molecule together with its ...
Mahmood Syed +3 more
doaj +1 more source
Drug-Release Mechanisms Elucidated by Imaging Techniques: Visualizing the Invisible!
Pharmaceutics, 2022 Imaging techniques such as Raman spectroscopy, electron microscopy, laser scanning confocal microscopy, atomic force microscopy, tomography, magnetic resonance imaging, and terahertz are powerful tools to elucidate drug-release mechanisms from different ...
Susanne Florin-Muschert
doaj +1 more source
Scientific Reports, 2013 Silicene, the considered equivalent of graphene for silicon, has been recently synthesized on Ag(111) surfaces. Following the tremendous success of graphene, silicene might further widen the horizon of two-dimensional materials with new allotropes ...
A. Resta +7 more
semanticscholar +1 more source