Results 191 to 200 of about 81,077 (285)

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, Volume 13, Issue 60, 28 October 2026.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

A study in SCARLET: investigating a new combination of therapies for KRAS G12C mutated non-small cell lung cancer. [PDF]

J Thorac Dis
Weber UM, Patil T.
europepmc   +1 more source

Repeated instillations of bleomycin in male mice induce a perivascular remodeling at distance of fibrotic areas in the context of progressive pulmonary fibrosis

Animal Models and Experimental Medicine, Volume 9, Issue 10, Page 1956-1963, October 2026.
We established a model of progressive pulmonary fibrosis via repeated intratracheal instillation (ITI) of leomycin (BLM) (A). Perivascular remodeling was observed in areas distant from the fibrotic areas and lesions induced by repeated ITI of BLM simulate those observed in IPF patients (B). Thus, this model has the capacity to track and investigate the
Céline‐Hivda Yegen, Zakaria Maakoul, Dominique Marchant, Patrice Callard, Julia Bourse, Jean‐François Bernaudin, Hilario Nunes, Carole Planès, Emilie Boncoeur, Nicolas Voituron   +9 more
wiley   +1 more source

Epidemiological characteristics and spatiotemporal analysis of scarlet fever in Guangzhou, China: the surveillance of 20 years. [PDF]

BMC Infect Dis
Lin HR, Wang J, Shan J, He Q, Dong S, Deng Q, Zhang M, Chen S, Luo L, Li Y, Liu Y.   +10 more
europepmc   +1 more source

Comparing Demographic and Clinical Features of Obstructive Sleep Apnea Patients With and Without Sleepiness: A Cross‐Sectional Study

Brain and Behavior, Volume 16, Issue 10, October 2026.
ABSTRACT Background Excessive daytime sleepiness (EDS) is a common but variable symptom in obstructive sleep apnea (OSA), with unclear associations with disease severity and clinical features. This study aimed to compare demographic and clinical characteristics of OSA patients with and without EDS in an Iranian population.
Fatemeh kashaninasab, Yousef Fathalian, Mahboobeh Khoozan, Mirfarhad Ghalehbandi, Nasim Nikoubakht   +4 more
wiley   +1 more source

Molecular Mechanisms and Therapeutic Advances in KRAS G12C‐Mutant Non‐Small Cell Lung Cancer: Toward Mechanism‐Guided Longitudinal Management

Cancer Innovation, Volume 5, Issue 5, October 2026.
This review summarizes the molecular mechanisms, clinical development, resistance patterns, and emerging treatment strategies of KRAS G12C‐mutated non‐small cell lung cancer, with emphasis on approved inhibitors, combination approaches, next‐generation agents, and future directions from both global and Chinese perspectives.
Haiying Wang, Hanxiao Chen, Sheng Li, Jun Zhao   +3 more
wiley   +1 more source

A Novel Homozygous Frameshift Variant in ZNF699 Associated With DEGCAGS Syndrome With Severe Transfusion‐Dependent Anemia in an Indian Child: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT In children with unexplained multisystem involvement—global developmental delay, dysmorphism, skeletal anomalies, and severe transfusion‐dependent anemia—especially from consanguineous families, whole‐exome sequencing should be pursued early to enable timely diagnosis, proactive iron chelation, and genetic counseling.
Arimanda Chaitanya Laasya Reddy, A. Vamshee Priya, Aditya Pachwa, Boilla Abhignya Reddy, Lakshya Nehal Samineni, Lanka Gourav Reddy   +5 more
wiley   +1 more source

Scarlet Fever

American Journal of Public Health and the Nations Health, 1936
openaire   +3 more sources

Introducing A Stepwise Anatomic Framework for Urogenital Reconstruction Derived From Orofacial Plastic Surgery Principles: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT We present a novel labial reconstruction technique in a 48‐year‐old woman with extensive bilateral labial defects caused by steatocystoma multiplex. An anatomy‐guided, stepwise approach integrating scalp and orofacial reconstructive principles enabled successful restoration using a rhomboid mucocutaneous flap, minimizing tissue tension while ...
Lynn Damitz, Mohammadamin Parsaei, Denniz Zolnoun   +2 more
wiley   +1 more source

Purification-Driven Modulation of Polyphenol Profile and Protein Glycation-Inhibitory Potential of <i>Actinidia arguta</i> and <i>Actinidia kolomikta</i> Fruit Extracts. [PDF]

Molecules
Szwengiel A, Sawicki T, Jabłońska M, Latocha P, Błaszczak W.   +4 more
europepmc   +1 more source