Results 31 to 40 of about 348,753 (249)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Planar microwave retroreflector based on transmissive gradient index metasurface
New Journal of Physics, 2020 In this paper, a novel planar microwave retroreflector based on a transmissive gradient metasurface combined with a curved metal mirror is proposed and demonstrated.
Yong-Qiang Liu +4 more
doaj +1 more source
IEEE Access, 2020 The Sommerfeld Integrals (SIs) are re-visited in the presence of half-spaces under the assumption of γ0 ≈ iλ being valid for low-frequency propagation in order to investigate the near-field due to a Horizontal Magnetic Dipole (HMD ...
Honglei Xu +5 more
doaj +1 more source
Scientific Reports, 2021 In the past decade neutron dark-field contrast imaging has developed from a qualitative tool depicting microstructural inhomogeneities in bulk samples on a macroscopic scale of tens to hundreds of micrometers to a quantitative spatial resolved small ...
Jacopo Valsecchi +5 more
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Monolithically integrated wide field-of-view metalens by angular dispersionless metasurface
Materials & DesignMeta-lenses, which are made by sub-wavelength metallic or dielectric elements, have attracted widespread attentions due to its unprecedented electromagnetic wave manipulation abilities and novel applications.
Yong-Qiang Liu +6 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Efficient Simulation Method for High Quality SAR Images of Complex Ground Vehicles
Leida xuebao, 2015 Aiming at meeting the requirement of the amass high-quality SAR images needed by template-based ground target recognition engineering practice, a novel efficient SAR signal level simulation method is proposed.
Dong Chun-zhu +3 more
doaj
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source