Results 41 to 50 of about 348,753 (249)

The Neutron Macromolecular Crystallography Instruments at Oak Ridge National Laboratory: Advances, Challenges, and Opportunities

open access: yesCrystals, 2018
The IMAGINE and MaNDi instruments, located at Oak Ridge National Laboratory High Flux Isotope Reactor and Spallation Neutron Source, respectively, are powerful tools for determining the positions of hydrogen atoms in biological macromolecules and their ...
Flora Meilleur   +4 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Order-disorder in room-temperature ionic liquids probed via methyl quantum tunneling

open access: yesStructural Dynamics, 2021
Room-temperature ionic liquids are promising candidates for applications ranging from electrolytes for energy storage devices to lubricants for food and cellulose processing to compounds for pharmaceutics, biotransformation, and biopreservation.
Eugene Mamontov   +2 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Evaluation of the Trapped Surface Wave of a Vertical Electric Dipole Based on Undetermined Coefficient Method in the Presence of N-Layered Region: A Graphical Approach

open access: yesInternational Journal of Antennas and Propagation, 2019
In previous studies, the trapped surface wave, which is defined by the residue sums, has been addressed in the evaluation of the Sommerfeld integrals describing electromagnetic field of a vertical dipole in the presence of three-layered or four-layered ...
Hong Lei Xu   +5 more
doaj   +1 more source

A Fast Algorithm for Establishing 3-D Scattering Center Model for Ship Targets over Sea Surface Using the Shooting and Bouncing Ray Technique

open access: yesLeida xuebao, 2019
Fast construction of the 3-D scattering centers of ship targets on the sea surface is important for many radar applications, including the fast signature prediction, feature extraction, and automatic recognition of targets.
YAN Hua   +5 more
doaj   +1 more source

Scattering Fans [PDF]

open access: yesInternational Mathematics Research Notices, 2018
AbstractScattering diagrams arose in the context of mirror symmetry, Donaldson–Thomas theory, and integrable systems. We show that a consistent scattering diagram with minimal support cuts the ambient space into a complete fan. A special class of scattering diagrams, the cluster scattering diagrams, is closely related to cluster algebras.
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Quantum wake dynamics in Heisenberg antiferromagnetic chains

open access: yesNature Communications, 2022
It has long been suggested that the inverse Fourier transform of neutron scattering data gives access to space- and time-resolved spin-spin correlations. Scheie et al.
A. Scheie   +6 more
doaj   +1 more source

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