Results 71 to 80 of about 2,212,367 (331)

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Neutrons reveal the dynamics of leaf thylakoids in living plants

Scientific Reports
The study is the first known exploration of photosynthetic membranes dynamics in living plants by high resolution quasielastic neutron scattering spectroscopy.
Laura-Roxana Stingaciu, Hugh O’Neill, Chung-Hao Liu, Barbara R. Evans, Gergely Nagy   +4 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Structural plasticity of SARS-CoV-2 3CL Mpro active site cavity revealed by room temperature X-ray crystallography

Nature Communications, 2020
The SARS-CoV-2 3CL main protease (3CL Mpro) is a chymotrypsin-like protease that facilitates the production of non-structural proteins, which are essential for viral replication and is therefore of great interest as a drug target.
Daniel W. Kneller, Gwyndalyn Phillips, Hugh M. O’Neill, Robert Jedrzejczak, Lucy Stols, Paul Langan, Andrzej Joachimiak, Leighton Coates, Andrey Kovalevsky   +8 more
doaj   +1 more source

XYZ-polarisation analysis of diffuse magnetic neutron scattering from single crystals

, 2010
Studies of diffuse magnetic scattering largely benefit from the use of a multi-detector covering wide scattering angles. Therefore, the different contributions to the diffuse scattering that originate from magnetic, nuclear coherent, and nuclear spin ...
Brückel Th, Maleyev S V, Maleyev S V, Schweitzer J, Schärpf O, Werner Schweika   +5 more
core   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Terahertz Radar Cross Section Measurements Based on Millimeter-wave Converter

Leida xuebao, 2018
The measurement system has been built with Stepped Frequency Continuous Wave (SFCW) signal for Radar Cross Section (RCS) measurements in free-space at 220～330 GHz.
Wu Yang, Bai Yang, Yin Hongcheng, Zhang Liangcong   +3 more
doaj   +1 more source

Low temperature scattering with the R-matrix method: argon-argon scattering

, 2019
Results for elastic atom-atom scattering are obtained as a first practical application of RmatReact, a new code for generating high-accuracy scattering observables from potential energy curves.
McKemmish, Laura K., Rivlin, Tom, Spinlove, K. Eryn, Tennyson, Jonathan   +3 more
core   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Multiple-Scattering Series For Color Transparency

, 1992
Color transparency CT depends on the formation of a wavepacket of small spatial extent. It is useful to interpret experimental searches for CT with a multiple scattering scattering series based on wavepacket-nucleon scattering instead of the standard one
A. H. Mueller, A. H. Mueller, A. S. Carroll, B. K. Jennings, B. K. Jennings, B. K. Jennings, B. K. Jennings, B. Pire, B. Z. Kopeliovich, B. Z. Kopeliovich, B. Z. Kopeliovich, F. E. Low, G. A. Miller, G. A. Miller, G. A. Miller, G. R. Farrar, H-n Li, J. Botts, J. Botts, J. Botts, J. Botts, J. Botts, J. Gunion, J. P. Ralston, J. P. Ralston, L. Frankfurt, L. Frankfurt, L. Frankfurt, L. Frankurt, N. N. Nikolaev, S. Heppelmann, S. J. Brodsky, S. J. Brodsky, S. Nussinov, W. R. Greenberg   +34 more
core   +1 more source