Results 171 to 180 of about 862,152 (305)

Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications

Advanced Science, EarlyView.
Targeted regulation of pyroptosis to modulate the immune landscape is a novel design strategy for cancer immunotherapy and anti‐inflammatory treatment. Pyroptosis, as a double‐edged sword, underscores the importance of optimizing the design strategy of functional materials and appropriately activating pyroptosis for the effective treatment of diseases.
Luyao Tian, Shuo Piao, Xia Li, Lanping Guo, Luqi Huang, Wenyuan Gao   +5 more
wiley   +1 more source

Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis

Advanced Science, EarlyView.
In this study, a mechanical biomimetic nanocomposite is developed, guided by photoacoustic imaging, to achieve highly efficient and safe thrombolysis through the synergistic effects of photothermal therapy and pharmacological intervention. Most notably, the nanoparticle improves the microenvironment of arterial thrombi, marked by high shear stress and ...
Ying Li, Qi Xiang, Yan Zhang, Fuxue Luo, Yunfang Wu, Haitao Ran, Yang Cao   +6 more
wiley   +1 more source

Intestinal SR-BI does not impact cholesterol absorption or transintestinal cholesterol efflux in mice

Journal of Lipid Research, 2013
Reverse cholesterol transport (RCT) can proceed through the classic hepatobiliary route or through the nonbiliary transintestinal cholesterol efflux (TICE) pathway.
Kanwardeep S. Bura, Caleb Lord, Stephanie Marshall, Allison McDaniel, Gwyn Thomas, Manya Warrier, Jun Zhang, Matthew A. Davis, Janet K. Sawyer, Ramesh Shah, Martha D. Wilson, Arne Dikkers, Uwe J.F. Tietge, Xavier Collet, Lawrence L. Rudel, Ryan E. Temel, J.Mark Brown   +16 more
doaj  

Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles [PDF]

, 2007
Eric D. Labonté, Philip N. Howles, Norman A. Granholm, Juan Camilo Rojas Echeverri, Joanna P. Davies, Yiannis A. Ioannou, David Y. Hui   +6 more
openalex   +1 more source

Secretory phospholipase A2 increases SR-BI-mediated selective uptake from HDL but not biliary cholesterol secretions⃞

Journal of Lipid Research, 2008
High density lipoprotein cholesterol represents a major source of biliary cholesterol. Secretory phospholipase A2 (sPLA2) is an acute phase enzyme mediating decreased plasma HDL cholesterol levels. Clinical studies reported a link between increased sPLA2
Uwe J.F. Tietge, Niels Nijstad, Rick Havinga, Julius F.W. Baller, Fjodor H. van der Sluijs, Vincent W. Bloks, Thomas Gautier, Folkert Kuipers   +7 more
doaj  

Scavenger receptor class B, type I (SR-BI) homo-dimerizes via its C-terminal region: Fluorescence resonance energy transfer analysis [PDF]

, 2007
Daisy Sahoo, Yinan Peng, Jeffery R. Smith, Yolanda F. Darlington, Margery A. Connelly   +4 more
openalex   +1 more source

Bacterial Capture‐Killing Capsules with Remodeling Bone Immune Microenvironment for the Effective Treatment of Osteomyelitis

Advanced Science, EarlyView.
The PC‐O@TOB capsules are designed to exhibit bactericidal effects, regulate the bone immune microenvironment by promoting M2 macrophage polarization, eliminate excessive ROS, and enhance bone regeneration, providing a novel multi‐dimensional approach for the treatment of osteomyelitis.
Dong Yang, Chang Shu, Chengwei Xu, Xingjie Zan, Shaoyin Wei, Chenglong Wang, Lianxin Li   +6 more
wiley   +1 more source

An Organic Chemist's Guide to Mediated Laccase Oxidation

ChemBioChem, Volume 23, Issue 23, December 5, 2022., 2022
The mediator‐assisted laccase‐catalyzed oxidation of alcohols is a green alternative to established classical synthetic protocols. However, the interaction between laccases, mediators and oxygen comprises a highly complicated, multivariate system. We present a detailed comparative study evaluating the most important components and parameters via an ...
Katharina Obleser, Hubert Kalaus, Bernhard Seidl, Martin Kozich, Christian Stanetty, Marko D. Mihovilovic   +5 more
wiley   +1 more source

Cartilage‐Penetrating Framework Nucleic Acid Nanoparticles Ameliorate Osteoarthritis by Promoting Drug Delivery and Chondrocyte Uptake

Advanced Science, EarlyView.
Based on the poor cartilage penetration of tFNA, a novel tFNA‐2WL with excellent cartilage permeability and perfect chondrocyte endocytosis properties is designed and fabricated. As a result, tFNA‐2WL has a nearly seven‐fold increase in the penetration depth into the cartilage, with the same excellent cell entry properties as tFNA.
Kui Huang, Qiumei Li, Huixuan Lin, Qian Shen, Yaping Wu, Taoran Tian, Chuan Ma, Sirong Shi, Jingang Xiao, Yunfeng Lin   +9 more
wiley   +1 more source

CD36 does not play a direct role in HDL or LDL metabolism

Journal of Lipid Research, 2001
CD36 and scavenger receptor class B, type I (SR-BI) are both class B scavenger receptors that recognize a broad variety of ligands, including oxidized low density lipoprotein (oxLDL), HDL, anionic phospholipids, and apoptotic cells.
Willem J.S. de Villiers, Lei Cai, Nancy R. Webb, Maria C. de Beer, Deneys R. van der Westhuyzen, Frederick C. de Beer   +5 more
doaj