Results 311 to 320 of about 103,100 (354)

The cellular biology of scavenger receptor class B type I

Current Opinion in Lipidology, 2001
The HDL receptor scavenger receptor class B type I plays an important role in meditating the uptake of HDL-derived cholesterol and cholesteryl ester in the liver and steroidogenic tissues. However, the mechanism by which scavenger receptor class B type I mediates selective cholesterol uptake is unclear.
David L. Silver, Alan R. Tall
openaire   +3 more sources

Functions of scavenger receptor class B, type I in atherosclerosis

Current Opinion in Lipidology, 2012
This review highlights the diverse roles of the high-affinity HDL receptor scavenger receptor class B, type I (SR-BI) in the modulation of global cholesterol homeostasis and vascular cell function, and the potential implications of these processes in atherosclerosis.SR-BI in the liver plays a critical role in reverse cholesterol transport and it ...
Chieko Mineo, Philip W. Shaul
openaire   +2 more sources

HDL scavenger receptor class B type I and platelet function

Current Opinion in Lipidology, 2011
HDL cholesterol levels have been inversely correlated with thrombosis and HDL has been shown to mediate various antithrombotic effects. However, molecular mechanisms underlying the suppressing effect of HDL on platelet reactivity are not completely understood.
Jerzy-Roch Nofer, Miranda Van Eck
openaire   +2 more sources

Scavenger Receptor Class B, Type I: A Promising Immunotherapy Target

Immunotherapy, 2011
Scavenger receptor class B, type I (SR-BI) is a crucial molecule in lipid metabolism, since the interaction of high-density lipoproteins (HDLs) with SR-BI is involved in reverse cholesterol transport and cholesterol efflux. Recent findings also underscore a critical role of SR-BI in antimicrobial and immune responses. SR-BI is not only highly expressed
Jessica Fioravanti, José Medina-Echeverz, Pedro Berraondo   +2 more
openaire   +3 more sources

HDL and Scavenger Receptor Class B Type I (SRBI)

2022
The scavenger receptor class B type I (SR-BI) is a versatile HDL receptor protein. It is highly expressed in liver and steroidogenic tissues. SR-BI regulates selective uptake of cholesterol ester (CE) from HDL, revealing its role in mediating reverse cholesterol transport (RCT) and steroid hormone synthesis.
openaire   +2 more sources

Interaction of scavenger receptor class B type I with peroxisomal targeting receptor Pex5p

Biochemical and Biophysical Research Communications, 2003
Scavenger receptor class B type I (SR-BI) is an HDL receptor that mediates selective HDL lipid uptake. Peroxisomes play an important role in lipid metabolism and peroxisomal targeting signal type 1 (PTS1)-containing proteins are translocated to peroxisomes by the peroxisomal targeting import receptor, Pex5p.
Jenny M. Johansson, Peter S. Eriksson, Per-Arne Svensson, Björn Carlsson, Maria A I Åberg, Magnus S. C. Johnson, Lena M. S. Carlsson   +6 more
openaire   +3 more sources

Activation of the rat scavenger receptor class B type I gene by PPARα

Molecular and Cellular Endocrinology, 2006
Peroxisomal proliferator activated receptor alpha (PPARalpha) is activated by fibrate drugs which are known to protect against atherosclerosis. The present study examines the effects of PPARalpha on SR-BI expression. For this study, a rat SR-BI promoter-luciferase reporter gene construct was co-transfected into different cell lines with expression ...
Mark P. McLean, Dayami Lopez
openaire   +3 more sources

Hyperglycemia suppresses hepatic scavenger receptor class B type I expression

American Journal of Physiology-Endocrinology and Metabolism, 2008
Hyperglycemia is a major risk factor for atherosclerotic disease. Hepatic scavenger receptor class B type I (SR-BI) binds HDL particles that mediate reverse cholesterol transport and thus lowers the risk of atherosclerosis. Here we examined glucose regulation of SR-BI gene expression in both HepG2 cells and whole animals. Results showed that hepatic SR-
Takamasa Nishiuchi, Toshihiko Ishida, Ke Chen, Norman C.W. Wong, Wen M. Cao, Xiao Yu, Koji Murao, Kensuke Matsumoto, Hitomi Imachi   +8 more
openaire   +2 more sources

Scavenger receptor class B type I polymorphisms and peripheral arterial disease

Metabolism, 2007
Genetic variations of the scavenger receptor class B type I (SR-BI) have been demonstrated to be associated with plasma lipid parameters, anthropomorphic parameters, and coronary artery disease. We determined the frequency of 3 single-nucleotide polymorphisms within the SR-BI gene (SCARB1) in 354 patients with peripheral arterial disease (PAD) and 354 ...
Andreas, Ritsch, Gudrun, Sonderegger, Gudron, Sonderegger, Anton, Sandhofer, Ursula, Stanzl, Ursala, Stanzl, Ivan, Tancevski, Philipp, Eller, Wilfried, Schgoer, Andreas, Wehinger, Thomas, Mueller, Meinhard, Haltmayer, Josef R, Patsch, Joseph R, Patsch   +13 more
openaire   +3 more sources