Results 21 to 30 of about 20,627 (152)

EFFECT OF β3-AR ON THE SCAVENGER RECEPTOR CLASS B TYPE 1 (SR-B1) AND ITS SIGNAL TRANSDUCTION MECHANISM IN MICE WITH APOLIPOPROTEIN E GENE KNOCKOUT [PDF]

Heart, 2012
Objectives To investigate the effects of β3-AR on the lipids, atherosclerosis plaques, scavenger receptor class B type 1 (SR-B1) and its signal transduction in mice with apolipoprotein E gene knockout. Methods Ten C57BL/6J mice (10 weeks) were ...
Guo yanqing, Li yanfang, Wang zhaohong, Li yanfang   +3 more
openaire   +1 more source

Rosuvastatin Reduces Aortic Sinus and Coronary Artery Atherosclerosis in SR-B1 (Scavenger Receptor Class B Type 1)/ApoE (Apolipoprotein E) Double Knockout Mice Independently of Plasma Cholesterol Lowering [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2018
Objective— Rosuvastatin has been widely used in the primary and secondary prevention of coronary heart disease. However, its antiatherosclerotic properties have not been tested in a mouse model that could mimic human coronary heart disease.
Yu, Pei, Xiong, Ting, Tenedero, Christine B., Lebeau, Paul, Ni, Ran, MacDonald, Melissa E., Gross, Peter L., Austin, Richard C., Trigatti, Bernardo L.   +8 more
openaire   +2 more sources

The evolution of the class A scavenger receptors [PDF]

, 2012
Background The class A scavenger receptors are a subclass of a diverse family of proteins defined based on their ability to bind modified lipoproteins. The 5 members of this family are strikingly variable in their protein structure and function, raising ...
McConkey, Brendan J., Meehan Conor J, E Bowdish Dawn M, G Brian Golding, McConkey Brendan J, Dawn M E Bowdish, Conor J Meehan, Golding G Brian, Brendan J McConkey, Meehan, Conor J., Fiona J Whelan, Whelan Fiona J, Golding, G. Brian, Whelan, Fiona J.; id_orcid, Bowdish, Dawn M.E.   +14 more
core   +1 more source

The Lymphocytic Scavenger Receptor CD5 Shows Therapeutic Potential in Mouse Models of Fungal Infection [PDF]

, 2021
Invasive fungal diseases represent an unmet clinical need that could benefit from novel immunotherapeutic approaches. Host pattern recognition receptors (e.g., Toll-like receptors, C-type lectins, or scavenger receptors) that sense conserved fungal cell ...
Velasco-de Andrés, María, Casadó-Llombart, Sergi, Carreras, Esther, Martínez-Florensa, Mario, Mourglia-Ettlin, Gustavo, Lozano, Francisco, Català, Cristina, Simões, Inês, Zaragoza, Óscar, García-Luna, Joaquín   +9 more
core   +1 more source

Three-dimensional Huh7 cell culture system for the study of Hepatitis C virus infection

Virology Journal, 2009
Background In order to elucidate how Hepatitis C Virus (HCV) interacts with polarized hepatocytes in vivo and how HCV-induced alterations in cellular function contribute to HCV-associated liver disease, a more physiologically relevant hepatocyte culture ...
Uprichard Susan L, TenCate Veronica, Sainz Bruno   +2 more
doaj   +1 more source

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease

Molecular Neurodegeneration, 2011
Background Reactive microglia are associated with β-amyloid (Aβ) deposit and clearance in Alzhiemer's Disease (AD). Paradoxically, entocranial resident microglia fail to trigger an effective phagocytic response to clear Aβ deposits although they mainly ...
Lin Nan, Zhu Yuan-gui, Pan Xiao-dong, Zhang Jing, Ye Qin-yong, Huang Hua-pin, Chen Xiao-chun   +6 more
doaj   +1 more source

Macrophage receptors responsible for distinct recognition of low density lipoprotein containing pyrrole or pyridinium adducts: models of oxidized low density lipoprotein

Journal of Lipid Research, 2000
Oxidation of low density lipoproteins (LDL) induced by incubation with Cu2+ ions results in the formation of a heterogeneous group of aldehydic adducts on lysyl residues (Lys) of apolipoprotein B (apoB) that are thought to be responsible for the uptake ...
Eugene A. Podrez, George Hoppe, June O'Neil, Lawrence M. Sayre, Nader Sheibani, Henry F. Hoff   +5 more
doaj   +1 more source

Class II Phosphoinositide 3-Kinases Contribute to Endothelial Cells Morphogenesis [PDF]

, 2013
PMCID: PMC3539993This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
I. Mavrommati, Piñeiro R, Chiozzotto, D, Tania Maffucci, G. Tibolla, Pineiro, R, Wheeler Ann P., Giuseppe Danilo Norata (104795), Wheeler, A., Ioanna Mavrommati, Maffucci Tania, Norata, G., Chiozzotto Daniela, Ioanna Mavrommati (104788), Tibolla Gianpaolo, Mavrommati, I, Maffucci, T, D. Chiozzotto, Falasca, M, Mavrommati Ioanna, Alberico Luigi Catapano, Roberto Piñeiro (104782), Mavrommati, I., Daniela Chiozzotto, Ann P Wheeler, R. Piñeiro, Gianpaolo Tibolla (104779), Norata GD, G.D. Norata, Norata Giuseppe Danilo, M. Falasca, Giuseppe Danilo Norata, Daniela Chiozzotto (104784), T. Maffucci, Catapano AL, Ann P. Wheeler (104791), Falasca Marco, Piñeiro Roberto, A.L. Catapano, Marco Falasca (104805), Chiozzotto D, Alberico Luigi Catapano (104799), Falasca, Marco, Wheeler AP, Falasca M, Maffucci T, Catapano, A., Mavrommati I, Norata, GD, Tibolla G, Piñeiro, R., Chiozzotto, D., Marco Falasca, Maffucci, T., Tibolla, G., Tibolla, G, Wheeler, AP, Roberto Piñeiro, Catapano Alberico Luigi, A. P. Wheeler, Gianpaolo Tibolla, Catapano, AL, Tania Maffucci (104802)   +62 more
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Class A scavenger receptor 1 (MSR1) restricts hepatitis C virus replication by mediating toll-like receptor 3 recognition of viral RNAs produced in neighboring cells

, 2013
Persistent infections with hepatitis C virus (HCV) may result in life-threatening liver disease, including cirrhosis and cancer, and impose an important burden on human health.
McGivern, David R., Fengyu Hu, Daisuke Yamane (206804), David R McGivern, Hu, Fengyu, Hiromichi Dansako (357935), Nobuyuki Kato (235685), Christoph Welsch (22852), Stanley M. Lemon (30543), Daisuke Yamane, Christoph Welsch, Welsch, Christoph, David R. McGivern (415119), Lemon, Stanley M., Kato, Nobuyuki, Fengyu Hu (415120), Dansako, Hiromichi, Stanley M Lemon, Yamane, Daisuke, Nobuyuki Kato, Hiromichi Dansako   +20 more
core   +1 more source

Innate immunity and neuroinflammation [PDF]

, 2013
Copyright © 2013 Abhishek Shastri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Kishore, U, Domenico Marco Bonifati, Abhishek Shastri, Shastri, A, Bonifati, DM, Uday Kishore   +5 more
core   +1 more source