Results 41 to 50 of about 20,627 (152)

Blue Mussel-Derived Bioactive Peptides PIISVYWK (P1) and FSVVPSPK (P2): Promising Agents for Inhibiting Foam Cell Formation and Inflammation in Cardiovascular Diseases

Marine Drugs
Atherosclerosis is a key etiological event in the development of cardiovascular diseases (CVDs), strongly linked to the formation of foam cells. This study explored the effects of two blue mussel-derived bioactive peptides (BAPs), PIISVYWK (P1) and ...
Chathuri Kaushalya Marasinghe, Jae-Young Je   +1 more
doaj   +1 more source

The Evolution of the Scavenger Receptor Cysteine-Rich Domain of the Class A Scavenger Receptors

, 2015
The class A Scavenger Receptor (cA-SR) family is a group of five evolutionarily related innate immune receptors. The cA-SRs are known for their promiscuous ligand binding; as they have been shown to bind bacteria such as Streptococcus pneumoniae, and ...
Whelan, Fiona Jane; id_orcid, Golding, G. Brian, Fiona J. Whelan, Dawn M. E. Bowdish, Nicholas V. L. Yap, Yap, Nicholas V.L., Bowdish, Dawn M.E., G. Brian Golding   +7 more
core   +1 more source

Scavenger Receptors Mediate Cellular Uptake of Polyvalent Oligonucleotide-Functionalized Gold Nanoparticles

, 2016
Mammalian cells have been shown to internalize oligonucleotide-functionalized gold nanoparticles (DNA-Au NPs or siRNA-Au NPs) without the aid of auxiliary transfection agents and use them to initiate an antisense or RNAi response.
Dan Zheng (144729), Pinal C. Patel (2144272), Chad A. Mirkin (16519), David A. Giljohann (2121100), Andrew E. Prigodich (2144269), Weston L. Daniel (2088454)   +5 more
core   +1 more source

Characterization of antibody-mediated neutralization directed against the hypervariable region 1 of hepatitis C virus E2 glycoprotein [PDF]

, 2010
The hypervariable region 1 (HVR1) comprising the first 27 aa of E2 glycoprotein is a target for neutralizing antibodies against hepatitis C virus (HCV), but the mechanisms of this neutralization in the cell-culture-infectious genotype 2a strain JFH1 ...
Dubuisson, J., J. Dubuisson, A. H. Patel, G. Vieyres, Patel, A.H., Vieyres, G.   +5 more
core   +1 more source

Unravelling the anti-inflammatory mechanisms of dietary fatty acids [PDF]

, 2009
Polyunsaturated fatty acids (PUFA) have been shown to modulate immune responses and have therapeutic effects in inflammatory disorders. The specific mechanisms of their actions have yet to be defined.
Dowling, Jennifer K.
core  

Expression of host defense scavenger receptors in spondylarthropathy.

, 2001
OBJECTIVE: Reactive arthritis (ReA) is postulated to be caused by a defective host defense against gram-negative bacteria. HLA-B27 could play a role in this process, but does not account for the many HLA-B27 negative patients. The objective of this study
GU, JR, SONG, YW, SAHLY, H, Seta, N., Gu, J., Baeten, Dominique, Yu, D. T., Baeten, D., SETA, N, Song, Y. W., KUIPERS, JG, Kirveskari, J., Veys, E. M., MAKSYMOWYCH, W, GRANFORS, K, YU, DTY, Granfors, K., Kuipers, J. G., Maksymowych, W., Sahly, H., Huang, F., Märker-Hermann, E., KIRVESKARI, J, HUANG, F, MARKER-HERMANN, E, Veys, Eric   +25 more
core   +1 more source

Enzymatically Degraded LDL Preferentially Binds to CD14 ^high CD16 ⁺ Monocytes and Induces Foam Cell Formation Mediated Only in Part by the Class B Scavenger-Receptor CD36

, 2001
—Heterogeneity of peripheral blood monocytes is characterized by specific patterns in the membrane expression of Fc γ-receptor III (FcγRIII/CD16) and the lipopolysaccharide receptor (LPS receptor CD14), allowing discrimination of distinct subpopulations.
Chinh Quoc Duong, Rothe, Gregor, Christa Büchler, Torzewski, Michael, Schmitz, Gerd, Duong, Chinh Quoc, Michael Kapinsky, Michael Torzewski, Büchler, Christa, Gerd Schmitz, Gregor Rothe, Kapinsky, Michael   +11 more
core   +1 more source

Characterizing Amino Acid Variations of Scavenger Receptors by Class Information Gain

, 2013
Conserved amino acids in sequences, which may be discovered as patterns across or along sequences, reveal functional domains within proteins. Conversely, less conserved amino acid sequences reveal areas of evolutionary divergence.
Lee, En Shiun Annie, Fiona J. Whelan, Dawn M. E. Bowdish, Whelan, Fiona J.; id_orcid, Wong, Andrew K.C., Andrew K. C. Wong, Bowdish, Dawn M.E., En-Shiun Annie Lee   +7 more
core   +1 more source

A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo [PDF]

, 2000
The strongest susceptibility genes for the development of systemic lupus erythematosus (SLE) in humans are null mutants of classical pathway complement proteins. There is a hierarchy of disease susceptibility and severity according to the position of the
H. Terence Cook, Savill, John, Henson, Peter M, Cook, HT, Valerie A. Fadok, Taylor, P.R, Henson, PM, Mark J. Walport, Savill, JS, Walport, MJ, Philip R. Taylor, John S. Savill, Michael C. Carroll, Botto, M, Andrews, Mark, Taylor, PR, Fadok, Valerie A, Anna Carugati, Carroll, Michael C, Walport, Mark J, Carroll, MC, Marina Botto, Carugati, A, Peter M. Henson, Andrews, M, Mark Andrews, Botto, Marina, Fadok, VA, Carugati, Anna, Cook, H. Terence   +29 more
core   +1 more source

Physiologic Regulation of Lipid Oxidation and Ferroptosis By Vitamin E, High-Density Lipoprotein, and Scavenger Receptor Class B Type 1

ABSTRACT Ferroptosis is a form of cell death caused by oxidative (-OOH) damage to phospholipids (PL) that comprise the cell membrane. Understanding mechanisms of ferroptosis is important because of the role it plays in human disease, including cancer and neurodegeneration.
Jonathan S. Rink, Andrea E. Calvert, Alexandra Moxley, Adam Yuh Lin, SonBinh T. Nguyen, Leo I Gordon, C. Shad Thaxton   +6 more
openaire   +1 more source