Results 41 to 50 of about 24,563,351 (251)

Heterogeneous Driver Modeling and Corner Scenarios Sampling for Automated Vehicles Testing

Journal of Advanced Transportation, 2022
Virtual simulation-based testing of autonomous vehicles (AVs) needs massive challenging corner cases to reach high testing accuracy. Current methods achieve this goal by finding testing scenarios with low sampling frequency in the empirical distribution.
Jingwei Ge, Huile Xu, Jiawei Zhang, Yi Zhang, Danya Yao, Li Li   +5 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Sensitivity Analysis for a Scenario-Based Reliability Prediction Model [PDF]

, 2005
As a popular means for capturing behavioural requirements, scenariosshow how components interact to provide system-level functionality.If component reliability information is available, scenarioscan be used to perform early system reliability assessment.
David S. Rosenblum, Genaína N. Rodrigues, Uchitel, S, Rodrigues, G, Sebastian Uchitel, Rosenblum, D   +5 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

The Superiority of Data-Driven Techniques for Estimation of Daily Pan Evaporation

Atmosphere, 2021
In the present study, estimating pan evaporation (Epan) was evaluated based on different input parameters: maximum and minimum temperatures, relative humidity, wind speed, and bright sunshine hours.
Manish Kumar, Anuradha Kumari, Deepak Kumar, Nadhir Al-Ansari, Rawshan Ali, Raushan Kumar, Ambrish Kumar, Ahmed Elbeltagi, Alban Kuriqi   +8 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Scenario-based component testing using embedded metadata

, 2004
We present an approach for the use case and scenario-based testing of software components. Use cases and scenarios are applied to describe the functional requirements of a software system. In our approach, a test is defined as a formalized and executable
Zdun, Uwe, Strembeck, Mark
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Adaptive vs. visionary-advocacy approaches in scenario planning : implications of contrasting purposes and constraint conditions [PDF]

, 2013
Includes bibliographical references.Scenario planning has steadily grown to become a significant part of business and organisational foresight processes, particularly where planning situations demand approaches beyond traditional forecasting, due to ...
Gordon, Adam Victor
core   +1 more source