Results 111 to 120 of about 5,220,122 (327)
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
Scenarios for Irish House Prices [PDF]
In this note, a recently published model of the Irish residential mortgage market is used to generate likely scenarios for Irish house prices out to 2013.
Kennedy, Gerard, McQuinn, Kieran
core
Sequence of multipolar transitions: Scenarios for URu2Si2
, 2005 d- and f-shells support a large number of local degrees of freedom: dipoles, quadrupoles, octupoles, hexadecapoles, etc. Usually, the ordering of any multipole component leaves the system sufficiently symmetrical to allow a second symmetry breaking ...
Fazekas, Patrik +2 more
core +2 more sources
Supersymmetric Scenarios with Dominant Radiative Neutralino Decay [PDF]
, 1996 The radiative decay of the next-to-lightest neutralino into a lightest neutralino and a photon is analyzed in the MSSM. We find that significant regions of the supersymmetric parameter space with large radiative BR's (up to about 100%) do exist.
A. Bartl +36 more
core +2 more sources
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
Moving Toward a Strategy for Addressing Climate Displacement of Marine Resources: A Proof-of-Concept
Frontiers in Marine Science, 2020 Realistic predictions of climate change effects on natural resources are central to adaptation policies that try to reduce these impacts. However, most current forecasting approaches do not incorporate species-specific, process-based biological ...
M. Cristina Mangano +21 more
doaj +1 more source
On Metric Perturbations in Brane-World Scenarios
, 2000 In this note we reconsider linearised metric perturbations in the one-brane Randall-Sundrum Model. We present a simple formalism to describe metric perturbations caused by matter perturbations on the brane and remedy some misconceptions concerning the ...
Akama +31 more
core +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Uncertainty in ensembles of global biodiversity scenarios
Nature Communications, 2019 While there is a clear demand for scenarios that provide alternative states in biodiversity with respect to future emissions, a thorough analysis and communication of the associated uncertainties is still missing.
W. Thuiller +4 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source