Results 281 to 290 of about 3,763,244 (397)

Lower, more frequent cisplatin dosing minimizes hearing loss in head and neck cancer. [PDF]

JCI Insight
Fernandez KA, Chowdhury AS, Bonczkowski A, Allen PD, Campbell MH, Lee DS, Malhotra C, Page BR, Mulford DA, Ortiz CE, Santa Maria PL, Kullar P, Khan SA, Newlands SD, Schmitt NC, Cunningham LL.   +15 more
europepmc   +1 more source

Amphiregulin and Epiregulin Confer Radioresistance in Esophageal Squamous Cell Carcinoma Through Oxidative Phosphorylation

Advanced Science, EarlyView.
Oxidative phosphorylation (OXPHOS) activity serves as a critical metabolic determinant of radiotherapy outcomes in esophageal squamous cell carcinoma (ESCC). The CEBPB/AREG/EREG axis drives radioresistance in ESCC by reprogramming OXPHOS. AREG and EREG function as predictive biomarkers for nCRT response and prognosis of ESCC patients.
Zhang Lin, Meilian Yao, Xin Xu, Dong Zhang, Lei Xu, Ling Rong, Xiaohang Wang, Yi Duan, Chengkun Chen, Jun Gu, Yao Zhang, Qiang Liu, Qing Ye, Gaoping Cui, Yujun Hao, Xiumei Ma   +15 more
wiley   +1 more source

Likelihood-Scheduled Score-Based Generative Modeling for Fully 3D PET Image Reconstruction. [PDF]

IEEE Trans Med Imaging
Webber G, Mizuno Y, Howes OD, Hammers A, King AP, Reader AJ.   +5 more
europepmc   +1 more source

Ratoon Season Rice Reduces Methane Emissions by Limiting Acetic Acid Transport to the Rhizosphere and Inhibiting Methanogens

Advanced Science, EarlyView.
This study finds that the interaction between ABA‐OsCIPK2‐OsSWEET1A reduces the allocation of methane producing bacteria carbon source (acetic acid) content to the rhizosphere soil of ratoon season rice, thereby reducing methane emissions. Abstract Rice paddies are a major, persistent source of atmospheric methane (CH4), emission rates depend on the ...
Jingnan Zou, Hailong Xu, Bin Qin, Chaojie Lan, Jinying Li, Bianhong Zhang, Huabin Zhang, Chunlin Guo, Hongfei Chen, Zhongming Fang, Quanzhi Zhao, Wenfei Wang, Changxun Fang, Zhixing Zhang, Wenxiong Lin   +14 more
wiley   +1 more source

A Novel Zinc(II) Complex for Sonodynamic Therapy Induces Pyroptosis of Breast Cancer Cells and Enhances Anti‐Tumor Immune Response

Advanced Science, EarlyView.
Although Zinc(II) complexes are effective in photodynamic therapy, their efficacy is limited by the poor tissue penetration of light. This work introduces a novel zinc(II) complex for sonodynamic therapy. Under ultrasound activation, it generates substantial singlet oxygen, induces pyroptosis in breast cancer cells, and promotes anti‐tumor immune ...
Sijie Wen, Dongsheng Tang, Lingpu Zhang, Hanchen Zhang, Zheng Cao, Kong Wai Tan, Xiaojun Wang, Haihua Xiao, Kun Shang   +8 more
wiley   +1 more source

Anesthesia Practice Shift Scheduling With a Generative Deep Learning Model. [PDF]

Cureus
Emeneker W, Heape S, Hartman G, Gillespie M, Perkins S.   +4 more
europepmc   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Understanding the roles of equine veterinary nursing teams in UK practices: A cross-sectional study. [PDF]

Vet Rec
Saul A, Pritchard P, Shrubb J, Robinson N, Stavisky J.   +4 more
europepmc   +1 more source

U‐Shaped Response of Flowering Time to Low and High Nitrogen via a Transcription Feedback Loop in Rice

Advanced Science, EarlyView.
The “seesaw effect” of Nhd1‐Ghd7 module in regulating flowering time (days to heading in rice) responses to nitrogen (N) via Hd3a/RFT1: deficient‐N (DN) delays flowering via Ghd7‐mediated suppression of Nhd1; moderate‐N (MN) impairs this suppression, enhancing Nhd1 to promote flowering; whereas superior‐N (SN) delays flowering by Nhd1‐activated ...
Shunan Zhang, Guanzhong Shou, Xianping Li, Xuemin Song, Xuesong Li, Junjie Guo, Jiaqiang Lu, Yi Jin, Hongye Qu, Ming Yan, Wona Ding, Ying Liu, Guohua Xu   +12 more
wiley   +1 more source

Using Machine Learning to Predict-Then-Optimize Elective Orthopedic Surgery Scheduling to Improve Operating Room Utilization: Retrospective Study.

JMIR Med Inform
Lex JR, Abbas A, Mosseri J, Singh Toor J, Simone M, Ravi B, Whyne C, Khalil EB.   +7 more
europepmc   +1 more source