MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Operating room planning and scheduling: A literature review. [PDF]
This paper provides a review of recent research on operating room planning and scheduling. We evaluate the literature on multiple fields that are related to either the problem setting (e.g.
Belien, Jeroen +2 more
core
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
A hybrid scatter search. Electromagnetism meta-heuristic for project scheduling. [PDF]
In the last few decades, several effective algorithms for solving the resource-constrained project scheduling problem have been proposed. However, the challenging nature of this problem, summarised in its strongly NP-hard status, restricts the ...
Debels, D +3 more
core
Motivational orientation and practice-scheduling patterns as correlates of self-regulated learning strategies in pre-professional cello students: a predictive-correlational study. [PDF]
Front PsycholKoca Ş, Altunoluk BM.
europepmc +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Agricultural Cyber-Physical Systems: Research Progress in Perception-Driven Multi-Robot Coordination and Logistics in Unstructured Environments. [PDF]
Sensors (Basel)Zhang J +5 more
europepmc +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
A heuristic methodology for solving spatial aresource-constrained project scheduling problems. [PDF]
In this paper we present a heuristic methodology for solving resource-constrained project scheduling problems with renewable and spatial resources. We especially concentrate on spatial resources that are encountered in construction projects, but our ...
Schatteman, Damien +3 more
core
Multi-task scheduling of self-driving laboratories under scientific constraints. [PDF]
Chem SciZhou J +6 more
europepmc +1 more source