Results 61 to 70 of about 89,645 (310)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
A genetic algorithm for dynamic scheduling in emergency departments with priorities [PDF]
, 2011 A hospital is a very complex environment and its management is a hard task. The point we explore in this thesis is the management of the patient flow for the Emergency Department. The main contribution of the thesis is twofold: on the one hand, we design
Bergamin, Filippo
core
A hybrid chemical reaction optimization scheme for task scheduling on heterogeneous computing systems [PDF]
, 2015 An application consisting of a group of tasks can be represented by a node- and edge-weighted directed acyclic graph (DAG), in which the vertices represent the computations and the directed edges represent the data dependencies as well as the ...
Xu, Yuming +4 more
core +1 more source
International Journal of Computational Intelligence SystemsThe workshop information scheduling system is a widely used management tool in the manufacturing industry. It can reasonably schedule and optimize production tasks in the workshop to improve production efficiency and reduce costs.
Zhe Yang
doaj +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
The relevance of outsourcing and leagile strategies in performance optimization of an integrated process planning and scheduling [PDF]
, 2008 Over the past few years growing global competition has forced the manufacturing industries to upgrade their old production strategies with the modern day approaches.
Tiwari, Manoj Kumar +6 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
A branch-and-bound algorithm for stable scheduling in single-machine production systems. [PDF]
Robust scheduling aims at the construction of a schedule that is protected against uncertain events. A stable schedule is a robust schedule that will change little when variations in the input parameters arise.
Herroelen, Willy, Leus, Roel
core
Research on emergency scheduling based on improved genetic algorithm in harvester failure scenarios
Frontiers in Plant ScienceIn response to the issue of harvesting machine failures affecting crop harvesting timing, this study develops an emergency scheduling model and proposes a hybrid optimization algorithm that combines a genetic algorithm and an ant colony algorithm.
Huanyu Liu +5 more
doaj +1 more source