FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Hybrid Meta-Heuristics for Robust Scheduling [PDF]
The production and delivery of rapidly perishable goods in distributed supply networks involves a number of tightly coupled decision and optimization problems regarding the just-in-time production scheduling and the routing of the delivery vehicles in ...
Dekker, R. +3 more
core
A Reinforcement Learning-Based Framework for Tariff-Aware Load Shifting in Energy-Intensive Manufacturing. [PDF]
Sensors (Basel)Leon-Medina JX +4 more
europepmc +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
A review of electro-hydrogen synergistic systems: from key material breakthroughs, multi-timescale control to full-chain integration. [PDF]
RSC AdvWang J, Hu B, Xu L, Fan X, Jiang J.
europepmc +1 more source
Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region
FEBS Open Bio, EarlyView.Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson +2 more
wiley +1 more source
Permutation Flowshop Scheduling with Earliness and Tardiness Penalties [PDF]
We address the permutation flowshop scheduling problem with earliness and tardiness penalties (E/T) and common due date of jobs. Large number of process and discrete parts industries follow flowshop type of production process.
Peeyush Mehta +2 more
core
Research on online EDI order scheduling optimization strategy in manufacturing enterprises based on time-varying Markov chains. [PDF]
Sci RepWulan Q.
europepmc +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
A two stage learning based knowledge driven evolutionary algorithm for energy efficient distributed hybrid flow shop scheduling problem with heterogeneous factories. [PDF]
Sci RepZhang ZQ, Bao HD, Xu YX, Qian B, Hu R.
europepmc +1 more source