Results 141 to 150 of about 241,676 (345)
Restless bandit marginal productivity indices I: singleproject case and optimal control of a make-to-stock M/G/1 queue [PDF]
, 2004 This paper develops a framework based on convex optimization and economic ideas to formulate and solve by an index policy the problem of optimal dynamic effort allocation to a generic discrete-state restless bandit (i.e. binary-action: work/rest) project,
Niño Mora, José
core +1 more source
A Sustainable Production Scheduling with Backorders under Different Forms of Rework Process and Green Investment [PDF]
, 2022 R. Udayakumar +5 more
openalex +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
, 2004 Nowadays, manufacturing industries -- driven by fierce competition and rising customer requirements -- are forced to produce a broader range of individual products of rising quality at the same (or preferably lower) cost. Meeting these demands implies an
Eiden, Wolfgang Anthony
core +1 more source
Optimal production scheduling for dairy industries [PDF]
, 2005 In this work, a complete two-level framework for use in food and in particular dairy industries is proposed. The specific characteristics of the dairy industry have been taken into consideration, in terms of the behavior of food sales over time and the ...
Alexandridis, Alex +3 more
core
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
S-Graph-Based Reactive Scheduling with Unexpected Arrivals of New Orders
MachinesManufacturing processes are often disrupted by unexpected events, such as machine breakdowns, raw material shortages, and the arrival of new orders. Effectively managing these uncertainties is crucial for maintaining the feasibility and optimality of the
Krisztián Attila Bakon +1 more
doaj +1 more source