Results 51 to 60 of about 1,782,050 (353)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Comparative study of different approaches to solve batch process scheduling and optimisation problems [PDF]

, 2012
Effective approaches are important to batch process scheduling problems, especially those with complex constraints. However, most research focus on improving optimisation techniques, and those concentrate on comparing their difference are inadequate ...
Huang, Wei, Sun, Yanming, Tan, Yaqing, Yue, Yong   +3 more
core  

B2C Mass Customization in the Classroom [PDF]

, 2012
The purpose of this article is to describe an internet-based mass customization assignment in Operations Management/Supply Chain Management classes where students utilize the Web site of a company that offers a customized product.
Gu, Qiannong, Khumawala, Basheer M., Visich, John K.   +2 more
core   +2 more sources

Environment-Aware Production Scheduling for Paint Shops in Automobile Manufacturing: A Multi-Objective Optimization Approach

International Journal of Environmental Research and Public Health, 2017
The traditional way of scheduling production processes often focuses on profit-driven goals (such as cycle time or material cost) while tending to overlook the negative impacts of manufacturing activities on the environment in the form of carbon ...
Rui Zhang
semanticscholar   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Production Scheduling of Multi-Stage, Multi-product Food Process Industries

, 2018
The production scheduling of a real-life multi-product, mixed batch and continuous food industrial facility is considered in this work. More specifically, the scheduling of canned fish production in a large-scale Spanish industry is studied in detail. The deployment of an efficient solution strategy is proposed to handle the computationally challenging
Georgiadis, Georgios P., Ziogou, Chrysovalantou, Kopanos, Georgios, Garcia, Manuel, Cabo, Daniel, Lopez, Miguel, Georgiadis, Michael C.   +6 more
openaire   +3 more sources

The challenge of integrating non-continuous processes-milk powder plant case study [PDF]

, 2009
The integration of non-continuous processes such as a milk powder plant present a challenge for existing process integration techniques. Current techniques are generally based on steady and continuous operation which for some industries is not the case ...
Atkins, Martin John, Neale, James R., Walmsley, Michael R.W.   +2 more
core  

Survival and disinfection of SARS-Cov-2 in environment and contaminated surface [PDF]

, 2020
The detection of SARS-Cov-2 in the sewage and water resources has increased the awareness among the people about the possibility survival of SARS-Cov-2 in the environment and the potential to transmit into the human through food chain or water resources.
Al-Gheethi, Adel, Al-Maqtari, Qais, Almoheer, Reyad, Hamdan, Rafidah, Noman, Efaq, Radin Mohamed, Radin Maya Saphira   +5 more
core  

Verification and Optimization of a PLC Control Schedule [PDF]

, 2000
We report on the use of the SPIN model checker for both the verification of a process control program and the derivation of optimal control schedules.
A. Fehnker, G.J. Holzmann, G.S. Shedler, K.G. Larsen, R. Alur, S. Yovine, T.. Ruys, T.A. Henzinger   +7 more
core   +2 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source