Results 71 to 80 of about 10,787,486 (301)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Digital EngineeringThere are engineering issues caused by the traditional energy scheduling model where the energy generation (source) adjusts according to the energy consumption (load) in textile industrial parks, leading to a disconnect between the energy system and the ...
Tianhao Tan +4 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Production Scheduling Based on a Multi-Agent System and Digital Twin: A Bicycle Industry Case
InformationThe emerging digitalization in today’s industrial environments allows manufacturers to store online knowledge about production and use it to make better informed management decisions. This paper proposes a multi-agent framework enhanced with digital twin
Vasilis Siatras +4 more
doaj +1 more source
Algorithms, 2014 Production processes in Cellular Manufacturing Systems (CMS) often involve groups of parts sharing the same technological requirements in terms of tooling and setup. The issue of scheduling such parts through a flow-shop production layout is known as the
Antonio Costa +2 more
doaj +1 more source
Improvement of the Scheduling of Automotive Testing Processes Based on Production Scheduling Methods
, 2023 AbstractIncreasing challenges in the automotive industry are caused by shorter development times for products, greater diversity of variants and increasing cost pressure. Testing plays an elementary role within the product development process (PDP). There are already many publications that deal with the early phases of the PDP, but relatively few that ...
Leon Stütz +3 more
openaire +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
A neural-based approach to production scheduling
, 1997 An effective neural-based approach to production scheduling is proposed in the paper, which is apt for solving complex job-shop scheduling problems with available time and due date constraints, constrained job-shop scheduling. Constraint network (CNN) is
Wang Haobo +7 more
core +1 more source