Results 71 to 80 of about 632,880 (290)
Synthesizing Proximate and Distal Levels of Explanation: Toward an Evolution-Informed Sociology
Frontiers in Sociology, 2018 In this paper, we argue that despite the growing acceptance of psychological research by mainstream sociologists, the discipline of sociology remains largely averse to biology.
Lawrence H. Williams +1 more
doaj +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Expertise Moderates Incidentally Learned Associations Between Words and Images
Frontiers in Psychology, 2018 Individuals with expertise in a domain of knowledge demonstrate superior learning for information in their area of expertise, relative to non-experts. In this study, we investigated whether expertise benefits extend to learning associations between words
Heather Bruett +8 more
doaj +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Semantics of Distinguishing Criteria: from Subjective to Intersubjective [PDF]
Interdisciplinary Description of Complex Systems, 2012 In this article we are aiming to build cognitive semantics over a first person perspective. Our goal is to specify meanings connected to cognitive agents, rooted in their experience and separable from language, covering a wide spectrum of cognitions ...
Martin Takac, Jan Sefranek
doaj
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
, 2019 Relativism about quantifiers maintains that we never quantify over an absolutely comprehensive domain. Some philosophers are quick to reject this view on the grounds that it cannot be coherently formulated. But not every coherent theory can be captured in a single thesis.
openaire +3 more sources