Results 101 to 110 of about 3,861,665 (292)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Schema Therapy – a powerful tool in management of Borderline Personality Disorder

Quality in Sport
Borderline Personality Disorder (BPD) is a clinically significant psychiatric condition characterized by fear of abandonment, emotional and interpersonal instability, identity disturbance, impulsivity, and self-harming or suicidal behaviors.
Igor Kłak, Jan Szerocki, Alicja Winkowska, Alina Grudina, Katarzyna Bartnik, Katarzyna Chwaleba, Katarzyna Milewska-Plis, Ksenia Mazur, Mariola Herian, Monika Karalus   +9 more
doaj   +1 more source

Dysfunctional schema modes in individuals with frontal lobe lesion; multiple CASE study analysis

Interdisciplinary Neurosurgery, 2019
Objectives: This study aimed to investigate the emotional, cognitive and behavioural responses of individuals with frontal lobe lesions. The study also sought to determine the coping and defence responses, as well as the executive functioning and higher ...
Sabir Zaman, Kehkashan Arouj, Dr., Shahid Irfan, Dr.   +2 more
doaj   +1 more source

The Influence of Social Priming on Speech Perception [PDF]

, 2012
Speech perception relies on auditory, visual, and motor cues and has been historically difficult to model, partially due to this multimodality. One of the current models is the Fuzzy Logic Model of Perception (FLMP), which suggests that if one of these ...
Broussard, Sierra N
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The Effectiveness of Schema Mode Therapy on Kind of Schema Process (in Mate-Selection) and Marriage Expectations in Girls In The Pre-marital Stage in Isfahan City [PDF]

پژوهش‌های علوم شناختی و رفتاری
The present study aimed to evaluate the effectiveness of schema mode therapy on the kind of schema process (in mate selection) and marriage expectations among girls in the pre-marital stage in Isfahan. The research design was a semi-experimental pre-test
Maedeh Sarshoghi, Maryam Fatehizadeh, Somaye Jaberi   +2 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Enhancing the EAST-ADL error model with HiP-HOPS semantics [PDF]

, 2014
EAST-ADL is a domain-specific modelling language for the engineering of automotive embedded systems. The language has abstractions that enable engineers to capture a variety of information about design in the course of the lifecycle — from requirements ...
Chen, De-Jiu, Lönn, Henrik, Papadopoulos, Yiannis, Sharvia, Septavera, Walker, Martin, Yuan, Wenjing   +5 more
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Short Communication: The need for open-source hardware, software, and data-sharing specifications in geomorphology [PDF]

Earth Surface Dynamics
Geomorphologists have more data and computational resources available than ever before. Collaboration between researchers specializing in different modes of inquiry (e.g.
A. J. Moodie, E. Barefoot, E. Hutton, C. Nguyen, A. D. Wickert, A. D. Wickert, J. Marr   +6 more
doaj   +1 more source