Results 81 to 90 of about 1,166,067 (259)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Evaluation of Relationship between Schemas and Panic Disorder through a Case Treated with Schema Therapy

Bilişsel Davranışçı Psikoterapi ve Araştırmalar Dergisi, 2014
Introduction: Schema therapy (ST) is a form psychoterapy combining existential, cognitive-behavioral, psychodynamic and object relation techniques that was developed by Jeffrey Young for personality disorders and severe behavioral pathology which are ...
Esra Yancar Demir, Gonca Soygüt
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

bowtie-json-schema/bowtie: v2023.05.13

, 2023
What's Changed New java implementation: dev.harrel:json-schema by @harrel56 in https://github.com/bowtie-json-schema/bowtie/pull/261 New Contributors @harrel56 made their first contribution in https://github.com/bowtie-json-schema/bowtie/pull/261 ...
Julian Berman, Greg Dennis, harrel56, Vishrut Aggarwal, Anish Kshirsagar, Noman Dhoni, Agnivesh Chaubey, Akanksha Kushwaha, Santhosh Kumar Tekuri, Jason Desrosiers   +9 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Dysfunctional schema modes in individuals with frontal lobe lesion; multiple CASE study analysis

Interdisciplinary Neurosurgery, 2019
Objectives: This study aimed to investigate the emotional, cognitive and behavioural responses of individuals with frontal lobe lesions. The study also sought to determine the coping and defence responses, as well as the executive functioning and higher ...
Sabir Zaman, Kehkashan Arouj, Dr., Shahid Irfan, Dr.   +2 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Comparing the efficacy of cognitive-behavioral therapy with the treatment of allegorical schema modes on psychotherapists burnout [PDF]

مجله علوم روانشناختی, 2023
Background: Job burnout is one of the psychological problems that threaten therapists. This problem can lead to a decrease in service quality. Cognitive-behavioral therapy and paradigmatic schema mentalities therapy are two intervention methods that have
Mohammad Faghanpour ganji, mehrdad kalantari, Ahmad abedi   +2 more
doaj