Results 71 to 80 of about 1,166,067 (259)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Putting Context into Schema Matching [PDF]

open access: yes, 2006
Attribute-level schema matching has proven to be an important first step in developing mappings for data exchange, integration, restructuring and schema evolution. In this paper we investigate contextual schema matching, in which selection conditions are
Elnahrawy, Eiman   +3 more
core  

Emotional self-states and coping responses in patients with chronic tinnitus: a schema mode model approach

open access: yesFrontiers in Psychiatry
BackgroundAmongst “third-wave” cognitive behavioural therapies, schema therapy demonstrates encouraging efficacy across various mental health conditions.
Benjamin Boecking   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

The Collection description schema forum [PDF]

open access: yes, 2004
A report on the one-day seminar on standard schemas for collection-level description, held by UKOLN in London on Thursday 12 February 2004. This seminar was aimed at information professionals involved in the policy, development and implementation of ...
Dunsire, Gordon, Dunsire, G.
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Parental burnout and depression among Iranian mothers: The mediating role of Maladaptive Coping modes

open access: yesBrain and Behavior, 2023
Objective Depression in mothers impacts children negatively. Understanding the antecedents and the underlying mechanisms of depression is essential in helping clinicians target depressive symptoms effectively.
Narges Sabzi   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

The website schema [PDF]

open access: yes, 2004
The website schema is conceptualized as the consumer's set of beliefs about information locations, and routes to those locations, on a website. A meta-analysis of three studies, one of them with a student sample and two with consumer samples, provides ...
Rossiter, J.R., Bellman, S.
core  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

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