Results 101 to 110 of about 1,166,067 (259)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

bowtie-json-schema/bowtie: v2023.08.8

, 2023
What's Changed Feature/dialects path by @harrel56 in https://github.com/bowtie-json-schema/bowtie/pull/379 Change PMD hook and move it to pre-commit config by @OptimumCode in https://github.com/bowtie-json-schema/bowtie/pull/383 Use pnpm in CI and ...
Julian Berman, Greg Dennis, harrel56, Kiran Tammana, Oleg Smirnov, Vishrut Aggarwal, Anish Kshirsagar, Noman Dhoni, Agnivesh Chaubey, Akanksha Kushwaha, Santhosh Kumar Tekuri, Jason Desrosiers   +11 more
core   +1 more source

“I feel [so alone] nothing” – emotional vulnerability and detachment as transdiagnostic key characteristics of patients with chronic tinnitus: a schema mode model approach

Frontiers in Psychiatry
BackgroundGold-standard approaches for chronic tinnitus involve hearing amplification measures and psychological therapy, where applicable. Whilst schema therapy is accumulating evidence as a transdiagnostically useful treatment framework, its ...
Benjamin Boecking, Petra Brueggemann, Birgit Mazurek   +2 more
doaj   +1 more source

Short Communication: The need for open-source hardware, software, and data-sharing specifications in geomorphology [PDF]

Earth Surface Dynamics
Geomorphologists have more data and computational resources available than ever before. Collaboration between researchers specializing in different modes of inquiry (e.g.
A. J. Moodie, E. Barefoot, E. Hutton, C. Nguyen, A. D. Wickert, A. D. Wickert, J. Marr   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Combatting comorbidity: the promise of schema therapy in substance use disorder treatment

Discover Psychology
This paper explores the bidirectional relationship between trauma and Substance Use Disorders (SUDs), emphasising the need for integrated treatment approaches.
Daniel Talbot, Logan Harvey, Victoria Cohn, Melanie Truscott   +3 more
doaj   +1 more source

Short-term group schema therapy for mixed personality disorders: A pilot study

Frontiers in Psychology, 2015
Schema Therapy has shown promising results for personality disorders but there is a limited evidence base for group Schema Therapy (ST-g) with mixed personality disorders.
Sally Ann Skewes, Rachel Anne Samson, Susan G Simpson, Michiel evan Vreeswijk   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Predicting Social Media Dependence Based on Schema Modes Considering Internal Anxiety in Adolescents [PDF]

تحقیقات سلامت در جامعه
Introduction and purpose: Social media dependency is considered a behavioral addiction that is accompanied by a range of negative psychological consequences for adolescents.
Afsaneh Erfanzadeh, Maryam Moghimian
doaj  

TREATING NARCISSISTIC PERSONALITY DISORDER WITH SCHEMA THERAPY – A CASE STUDY

Anthropological Researches and Studies
Objectives. This case study endeavors to provide an in-depth understanding of the schema and mode structure of narcissistic personality disorder (NPD) and to illustrate a possible therapeutic approach using schema therapy (ST). Material and methods.
Maria Cristina STERIE
doaj   +1 more source