Results 101 to 110 of about 18,431 (234)
, 1999 The following is a study of what may be the most puzzling and yet, at the same time, most significant aspect of Kant's system: his theory of schemata. I will argue that Kant's commentators have failed to make sense of this aspect of Kant's philosophy. A
Hunter, Joseph L.
core
Meaningfulness of Religious Language in the Light of Conceptual Metaphorical Use of Image Schema: A Cognitive Semantic Approach [PDF]
Religious Inquiries, 2013 According to modern religious studies, religions are rooted in certain metaphorical representations, so they are metaphorical in nature. This article aims to show, first, how conceptual metaphors employ image schemas to make our language meaningful, and ...
Javad Taheri, Mahshid Alvandi
doaj
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Searching of correspondences between data conceptual schemata
Revista Cubana de Ciencias Informáticas, 2014 In the context of conceptual data modeling, view integration refers to the activity of integrating and unifying different conceptual schemata modeled over a universe of discourse in a global schema.
Javier Agustín González +3 more
doaj
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Schemata and reading comprehension [PDF]
, 1985 t school, and also after formal schooling takes place, the acquisition of new knowledge is in great measure dependent on reading comprehension. The total task of understanding written discourse depends on the distribution of information in the printed ...
Meurer, José Luiz
core
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source