Results 51 to 60 of about 8,289 (203)

Epigenetic Clock Analysis of Sex Chromosome Aneuploidies

Aging Cell, Volume 24, Issue 11, November 2025.
Next‐generation epigenetic clocks indicate lower age acceleration and slower pace of aging in 47,XXY than 46,XX, 46,XY, and 47,XYY. A first‐generation clock (Skin & Blood) indicates higher age acceleration in 47,XXY and 47,XYY than 46,XY, while higher naïve CD8+ T in 47,XXY than both 46,XY and 46,XX suggests reduced immunosenescence.
Joshua Zhang, Jordan Teoli, Benjamin Rey, Cristina Vieira, Jean‐François Lemaitre, Ingrid Plotton, Gabriel A. B. Marais, Steve Horvath   +7 more
wiley   +1 more source

Parafusos pediculares no tratamento da cifose de Scheuermann: resultados e complicações Pedicle screws in the treatment of Scheuermann's kyphosis: results and complications

Revista Brasileira de Ortopedia, 2008
O tratamento cirúrgico da cifose de Scheuermann permanece um tópico em debate. Tratamento tradicional tem incluído liberação anterior associada à fusão dos segmentos discais apicais, seguida por instrumentação posterior.
Rodrigo D'Alessandro de Macedo, Márcio Fim, Bruno Pinto Coelho Fontes   +2 more
doaj   +1 more source

Impact of Sagittal Reference Lines on Predicting Distal Junctional Kyphosis in Adolescent Idiopathic Scoliosis

Orthopaedic Surgery, Volume 17, Issue 11, Page 3222-3229, November 2025.
This study investigated the effectiveness of sagittal stable vertebra (SSV) determined by different sagittal reference lines in predicting the risk of postoperative distal junctional kyphosis (DJK) in adolescent idiopathic scoliosis (AIS) patients who underwent posterior spinal fusion (PSF) with the lowest instrumented vertebra (LIV) at or above L1 ...
Po‐Yao Wang, Chih‐Wei Chen, Chuan‐Ching Huang, Jui‐Yo Hsu, Yuan‐Fuu Lee, Yu‐Cheng Yeh, Ming‐Hsiao Hu, Po‐Liang Lai, Shu‐Hua Yang   +8 more
wiley   +1 more source

PIEZO1‐GPX4 Axis Mediates Mechanical Stress‐Induced Vertebral Growth Plate Dysplasia via Ferroptosis Activation

Advanced Science, Volume 12, Issue 39, October 20, 2025.
Mechanical stress activates PIEZO1 in vertebral growth plate chondrocytes, triggering ferroptosis through direct binding and inhibition of GPX4. This axis promotes lipid peroxidation and pathological ossification, accelerating spinal deformities. Clinical and genetic evidence (Piezo1‐cKO) confirms its role in scoliosis progression.
Fei Chen, Fushuai Peng, Shuqing Chen, Yukun Du, Jianyi Li, Yuanyuan Fan, Zichen Cui, Guanghui Gu, Han Zhang, Zhensong Jiang, Guodong Wang, Xingzhi Jing, Jun Dong, Tao Li, Yongming Xi   +14 more
wiley   +1 more source

The Blood Ontology: An ontology in the domain of hematology [PDF]

, 2011
Despite the importance of human blood to clinical practice and research, hematology and blood transfusion data remain scattered throughout a range of disparate sources.
Barcellos, Almeida Mauricio, Carneiro, Proietti Anna Barbara de Freitas, Jiye, Ai, Smith, Barry   +3 more
core   +1 more source

Altered density of glomerular binding sites for atrial natriuretic factor in bile duct-ligated rats with ascites [PDF]

, 1991
The renal response to atrial natriuretic factor is blunted in cirrhosis with ascites. This might be due to alterations of renal receptors for atrial natriuretic factor.
Almeida, Arendt, Arendt, Ballermann, Cantin, Chinkers, De Léan, Epstein, Garcia, Gauquelin, Gauquelin, Gerbes, Gerbes, Gerbes, Gerbes, Gines, Kollenda, Kollenda, Kountouras, Laffi, Lang, Lowry, Maack, Misra, Morgan, Munson, Needleman, Olivera, Panos, Petrillo, Salerno, Thibault   +31 more
core   +1 more source

Truncating Variants in RREB1 Cause a Novel RASopathy Syndrome of Congenital Heart Disease, Genitourinary Malformations, and Developmental Delay

American Journal of Medical Genetics Part A, Volume 197, Issue 10, October 2025.
ABSTRACT The interstitial 6p microdeletion syndrome is characterized by dysmorphic facies and structural heart, kidney, brain, and musculoskeletal differences. RREB1 haploinsufficiency and consequent abnormal RAS‐MAPK pathway signaling have been proposed as a driver of the disease phenotype; however, apart from a single case report, the phenotype of ...
Alanna Strong, Caoimhe McKenna, Karen Stals, Antonio Vitobello, Mathilde Renaud, Claudine Rieubland, Michel Guipponi, Christophe Philippe, Paul Vrana, Alisa Gaskell, A. Micheil Innes, Alyssa L. Rippert, Rebecca Ahrens‐Nicklas, Elizabeth Bhoj, Kiersten Keller, Bimal P. Chaudhari, Brandon S. Stone   +16 more
wiley   +1 more source

An evolutionary approach to the representation of adverse events [PDF]

, 2009
One way to detect, monitor and prevent adverse events with the help of Information Technology is by using ontologies capable of representing three levels of reality: what is the case, what is believed about reality, and what is represented.
Capolupo, Maria, Ceusters, Werner, De Moor, Georges, Smith, Barry   +3 more
core   +1 more source

Increased plasma viscosity as a reason for inappropriate erythropoietin formation [PDF]

, 1993
The aim of this study was to examine whether altered plasma viscosity could contribute to the inappropriately low production rate of erythropoietin (EPO) observed in patients suffering from hypergammaglobulinemias associated with multiple myeloma or ...
Eckardt, Kai-Uwe, Götz, Karlheinz, Hamann, M., Kurtz, Armin, Ratcliffe, P. J., Reinhart, W. H., Singh, A., Zimmermann, A.   +7 more
core   +2 more sources

Comparative Assessment of Whole Organ Tissue Processing Methods for the Isolation of Extracellular Vesicles From Intact Organs

Journal of Extracellular Vesicles, Volume 14, Issue 9, September 2025.
ABSTRACT Extracellular vesicles (EVs) are small anuclear cellular membrane encapsulated fragments of importance for cellular interaction and transfer of information. These small vesicles, diverse in size and functionality, can be obtained from cells, tissues and bodily fluids. A complicated step for obtaining EVs from whole organs is understanding the
Mohammed Tayab Hussain, Shani Austin‐Williams, Joel McCay, Hedayatullah Hayat, Thomas D. Wright, Marilena Christoforou, Ella Ykema, Mauro Perretti, Dianne Cooper, Andreas Margraf   +9 more
wiley   +1 more source