Results 101 to 110 of about 61,070 (300)

Introduction to Schiff Base

, 2023
When any primary amine reacts with an aldehyde or a ketone under specific conditions, Schiff bases are formed. The general structure of Schiff base is R2C∙NR′ and is considered as a subclass of imines which is commonly used as a synonym for azomethine.
openaire   +2 more sources

Bifidobacterium Pseudolongum‐Derived Acetate Attenuates Acute Pancreatitis Through GPR43‐Mediated Suppression of M1 Macrophage Polarization

Advanced Science, EarlyView.
The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan, Xueyang Li, Cong He, Pan Zheng, Yaoyu Zou, Qi Zhu, Xin Li, Jie Liang, Junmin Yang, Li Zhang, Yuman Ye, Jianhua Wan, Huajing Ke, Jianping Liu, Nonghua Lu, Nianshuang Li, Yin Zhu   +16 more
wiley   +1 more source

The Frenet Serret Description of Gyroscopic Precession [PDF]

, 1993
The phenomenon of gyroscopic precession is studied within the framework of Frenet-Serret formalism adapted to quasi-Killing trajectories. Its relation to the congruence vorticity is highlighted with particular reference to the irrotational congruence ...
B. R. Iyer, B.R. Iyer, B.R. Iyer, C. V. Vishveshwara, C.V. Vishveshwara, C.W. Misner, D. Tsoubelis, D. Wilkins, E. Honig, K.S. Thorne, K.S. Thorne, N. Ashby, R.D. Greene, R.T. Jantzen, S.W. Hawking, W. Rindler   +15 more
core   +3 more sources

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

Polymeric Schiff bases. 17 - Azomethine copolymers [PDF]

Chemical synthesis of azomethine copolymers by melt polymerization techniques - polymeric Schiff ...
Dalelio, G. F., Feigl, D. M., Schoenig, R. K., Strazik, W. F.   +3 more
core   +1 more source

Crystal structure of 3-benzoyl-2-[(5-bromo-2-Hydroxy-3-methoxybenzylidene)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene [PDF]

, 2015
In the cyclo­hexene ring of the title compound, C23H20BrNO3S, the -(CH2)4- atoms are positionally disordered [occupancy ratio = 0.753 (6):0.247 (6)]. The ring has a half-chair conformation for both the major and minor components.
Byrappa, K., Glidewell, C., Jasinski, J.P., Kaur, M., Stoeckli-Evans, H., Yathirajan, H.S.   +5 more
core   +3 more sources

Engineered Bacteria Factory Integrating Drug Delivery and Antibody Manufacture for Activating the STING Signal Pathway Mediated Tumor Immunotherapy

Advanced Science, EarlyView.
To address the limitations of protein‐based ICIs in applications, this study constructed an engineered bacterium, HRB, capable of expressing aCD47 in hypoxic TME. Through the Schiff base reaction, responsive liposomes (LC) loaded with the STING agonist cGAMP were connected to the surface of bacteria to form HRB@LC.
Peng‐Shuo Dong, Tian Yao, Yong Li, Zi‐Hui Yan, Xiao‐Ting Xie, Jia‐Hua Zou, Kai Cheng, Jin‐Xuan Fan, Yuan‐Di Zhao, Qiu‐Ran Xu   +9 more
wiley   +1 more source

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Inactivation of Mandelate Racemase by 3-Hydroxypyruvate Reveals a Potential Mechanistic Link between Enzyme Superfamilies [PDF]

, 2015
Mandelate racemase (MR), a member of the enolase superfamily, catalyzes the Mg2+-dependent interconversion of the enantiomers of mandelate. Several α-keto acids are modest competitive inhibitors of MR [e.g., mesoxalate (Ki = 1.8 ± 0.3 mM) and 3 ...
Bearne, Stephen L., Nagar, Mitesh, St. Maurice, Martin, Wyatt, Brittney N.   +3 more
core   +1 more source

Hydrogen bonding interactions of benzylidene type Schiff bases studied by vibrational spectroscopic and computational methods [PDF]

, 2003
The structural features of four benzylidene type Schiff bases [(E)-benzaldehyde-N-phenyl imine, (A) (E)-2-hydroxybenzaldehyde-N-phenyl imine (B) (E)-benzaldehyde-N-2-hydroxyphenyl imine (C) (E)-2-hydroxybenzaldehyde-N-2-hydroxyphenyl imine (D)] were ...
Aakeroy, Baker, Bondi, Cohen, Csaba Hetényi, Császár, Devlin, Filarowski, Hoshino, Inabe, István Pálinkó, Ledbetter, Ledbetter, Ligtenbarg, Lindeman, Meic, Minkin, Ostrowska, Ottó Berkesi, Rozwadowski, Scott, Smith, Stewart, Stewart, Tamás Körtvélyesi, Tamás Németh, Voet, Wozniak   +27 more
core   +1 more source