Results 91 to 100 of about 65,479 (293)

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, Volume 90, Issue 12, December 10, 2025.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

Advances in the Gut‐Lung Axis and Bronchial Asthma: From Mechanisms to Therapeutic Potential

Clinical and Translational Allergy, Volume 15, Issue 12, December 2025.
ABSTRACT Background Bronchial asthma (hereafter referred to as asthma) is a heterogeneous disease characterized by chronic airway inflammation, airway hyperresponsiveness (AHR), and reversible airflow limitation. Recent advancements in the “gut‐lung” axis concept have elucidated the intricate immunometabolic crosstalk between the gastrointestinal tract
Ting Zheng, Yi Huang, Hongmei Yao
wiley   +1 more source

Asian Schistosomiasis: Current Status and Prospects for Control Leading to Elimination

Tropical Medicine and Infectious Disease, 2019
Schistosomiasis is an infectious disease caused by helminth parasites of the genus Schistosoma. Worldwide, an estimated 250 million people are infected with these parasites with the majority of cases occurring in sub-Saharan Africa.
Catherine A. Gordon, Johanna Kurscheid, Gail M. Williams, Archie C. A. Clements, Yuesheng Li, Xiao-Nong Zhou, Jürg Utzinger, Donald P. McManus, Darren J. Gray   +8 more
doaj   +1 more source

Genome-wide identification of Schistosoma japonicum microRNAs using a deep-sequencing approach. [PDF]

PLoS ONE, 2009
BackgroundHuman schistosomiasis is one of the most prevalent and serious parasitic diseases worldwide. Schistosoma japonicum is one of important pathogens of this disease.
Jian Huang, Pei Hao, Hui Chen, Wei Hu, Qing Yan, Feng Liu, Ze-Guang Han   +6 more
doaj   +1 more source

Kerentanan Schistosoma Japonicum Terhadap Praziquantel Di Napu Dan Lindu, Sulawesi Tengah Indonesia [PDF]

, 2016
Schistosomiasis in Indonesia are found in Napu, Lindu and Bada highland, Central Sulawesi. This disease was caused by Trematode worm, Schistosoma japonicum. Schistosomiasis still a public health problem which its prevalence increase every year. The large
AG, T. (Triwibowo), Nurwidayati, A. (Anis), PFS, P. (Phetisya), Risti, R. (Risti)   +3 more
core   +2 more sources

Multidisciplinary Preclinical Investigations on Ferrocenyl, Ruthenocenyl, and Benzyl Derivatives of Niridazole as New Drug Candidates against Schistosomiasis

ChemMedChem, Volume 20, Issue 23, November 28, 2025.
Novel organometallic derivatives of niridazole are designed, synthesized, and tested against Schistosoma mansoni. Schistosomiasis affects hundreds of millions of people worldwide, yet its chemotherapeutic treatment is based on the only drug available‐praziquantel (PZQ).
Tanja Karpstein, Shuai Zhong, Sarah Keller, Philipp Späne, Cécile Häberli, Gordana Panic, Olivier Blacque, Alex Odermatt, Kevin Cariou, Gilles Gasser, Jennifer Keiser   +10 more
wiley   +1 more source

Expression of microRNA-454 in TGF-β1-stimulated hepatic stellate cells and in mouse livers infected with Schistosoma japonicum

Parasites & Vectors, 2014
Background In the process of hepatic fibrosis, hepatic stellate cells (HSCs) can be activated by many inflammatory cytokines. The transforming growth factor-β1 (TGF-β1) is one of the main profibrogenic mediators.
Dandan Zhu, Xue He, Yinong Duan, Jinling Chen, Jianxin Wang, Xiaolei Sun, Hongyan Qian, Jinrong Feng, Wei Sun, Feifan Xu, Lingbo Zhang   +10 more
doaj   +1 more source

New approaches to measuring anthelminthic drug efficacy: parasitological responses of childhood schistosome infections to treatment with praziquantel [PDF]

, 2015
By 2020, the global health community aims to control and eliminate human helminthiases, including schistosomiasis in selected African countries, principally by preventive chemotherapy (PCT) through mass drug administration (MDA) of anthelminthics ...
A Danso-Appiah, A Fenwick, A Montresor, A Vidyashankar, AC Gelman, AE Butterworth, AL Bustinduy, Alexandra U. Scherrer, AU Scherrer, B Levecke, BM Bolker, CH King, Charles H. King, CJL Murray, CL Black, D Alonso, D Bates, F Thiongo, G Raso, Giovanna Raso, GR Olds, IM Silva, J Cabaret, J Modha, J Smith, J Utzinger, J Utzinger, J Utzinger, J. Russell Stothard, JA Hanley, JC Sousa-Figueiredo, JD Hadfield, Jean T. Coulibaly, José Carlos Sousa-Figueiredo, JP Webster, JT Coulibaly, Jürg Utzinger, K Stete, Katarina Stete, M Albonico, M Booth, M Ismail, M Nielsen, M Reddy, M Walker, Maria-Gloria Basáñez, Martin Walker, ME Mejía, MEJ Woolhouse, MG Basáñez, MJ Bockarie, MJ Doenhoff, MJ Doenhoff, P Andrews, P Fallon, PH Lamberton, Piero L. Olliaro, PJ Brindley, PJ Diggle, PJ Hotez, PL Olliaro, PNM Mwinzi, R Core Team, S Anayi, SD Melman, SJ Vlas de, SN Lahiri, SV Subramanian, Tarub S. Mabud, TW Jia, U Halekoh, W Harnett, W Wang, World Health Organization, World Health Organization, World Health Organization   +75 more
core   +4 more sources

Zoonotic Schistosomiasis: The Crossroads Between Animal and Human Schistosomiasis in Africa: Narrative Review

Health Science Reports, Volume 8, Issue 11, November 2025.
ABSTRACT Background The fight against schistosomiasis (urogenital and intestinal) has prolonged more than expected with more areas that were previously known to have less or no incidence of infection now recording alarming incidence rate. Researchers and stakeholders are now concerned about what is probably sustaining the possible infection, and one of
Fatima Amponsah Fordjour, Alexander Kwarteng   +1 more
wiley   +1 more source

Development of monoclonal antibodies against Sj29 and its possible application for schistosomiasis diagnosis

International Journal of Infectious Diseases, 2017
Objective: Timely Schistosoma japonicum detection improves outcomes in schistosomiasis. Here, we established a double antibody sandwich ELISA to detect Schistosoma japonicum.
Cui-Ping Ren, Quan Liu, Feng-Chun Liu, Feng-Yu Zhu, Shi-Xiang Cui, Zhen Liu, Wen-Da Gao, Miao Liu, Yong-Sheng Ji, Ji-Jia Shen   +9 more
doaj   +1 more source