Results 91 to 100 of about 15,657 (202)

Nitric oxide blocks the development of the human parasite Schistosoma japonicum [PDF]

, 2017
Human schistosomiasis, caused by Schistosoma species, is a major public health problem affecting more than 700 million people in 78 countries, with over 40 mammalian host reservoir species complicating the transmission ecosystem.
Ayala, FJ, Chen, Y-F, He, P, Hide, G, Lai, D-H, Li, M-Y, Lun, Z-R, Shen, J, Sun, X, Wang, L-F, Wilson, RA, Wu, Z-D, Yang, T-B, Yu, Z-L   +13 more
core   +1 more source

Docosahexaenoic Acid Inhibits p62‐Dependent Autophagy by Targeting HSP70A1A/TGM‐2 Axis to Alleviate Arecoline‐Induced Oral Submucosal Fibrosis

Journal of Food Biochemistry, Volume 2025, Issue 1, 2025.
Background: The role of docosahexaenoic acid (DHA) in fibrosis of other organs has been studied, but its function in oral submucous fibrosis (OSF) has not been reported. This study aimed to investigate the role and mechanism of DHA in OSF. Methods: OSF rat and cell models were established induced by arecoline.
Zhaoyong Hu, Yuzhe Dai, Chenwei Wang, Yanli Liu, Qun Li, Qiaojuan Zuo, Ruiyi Chen, Jin Tan, Xuelin Zhou   +8 more
wiley   +1 more source

Neglected Tropical Diseases and Female Infertility: Possible Pathophysiological Mechanisms

Journal of Tropical Medicine, Volume 2025, Issue 1, 2025.
Battling female infertility has posed a global challenge, where neglected tropical diseases (NTDs) are nonetheless a notable contributing factor. NTDs affect a variety of diseases, often of a chronic nature, which are often cited as some of the most lethal diseases operating against the most economically disadvantaged populations across the globe.
Moses Agbomhere Hamed, Olabanji Ahmed Surakat, Victor Olukayode Ekundina, Kabirat Bolajoko Jimoh, Adetomiwa Ezekiel Adeogun, Nafisat Omolola Akanji, Oluwafemi Joshua Babalola, Patrick Chukwunonso Eya, Rajib Chowdhury   +8 more
wiley   +1 more source

Identification and validation of a Schistosoma japonicum U6 promoter

Parasites & Vectors, 2017
Background RNA polymerase III promoters have been widely used to express short hairpin-RNA (shRNA), microRNA (miRNA), and small guide RNA (sgRNA) in gene functional analysis in a variety of organisms including Schistosoma mansoni.
Qing Li, Wan Wang, Nan Zhao, Pengcheng Li, Yue Xin, Wei Hu   +5 more
doaj   +1 more source

Do schistosome vaccine trials in mice have an intrinsic flaw that generates spurious protection data? [PDF]

, 2016
The laboratory mouse has been widely used to test the efficacy of schistosome vaccines and a long list of candidates has emerged from this work, many of them abundant internal proteins.
A Dessein, AP Mountford, AP Mountford, AV Wisnewski, AW Cheever, B Nare, BC Figueiredo, BL Mangold, BL Mangold, C Carvalho-Queiroz, CC Alves, CC Tang, CL Sokol, CS Pinheiro, CX Yu, D Boulanger, D Lin, D Moser, DA Dean, DA Dean, DA Dean, DA Vignali, DS Yole, DS Yole, DW Dunne, E Long, EC Ratcliffe, EJ Pearce, EK Birks, FC Cardoso, G Ahmad, GS Philippsen, GV Hillyer, GV Hillyer, H Chen, IW Chalmers, J Yu, JB West, JE Crabtree, JE Crabtree, JE Crabtree, JE Portielje, JL Abane, JL Yu, JP Hewitson, KD Murrell, KS Warren, KY Park, L Argiro, LA Soisson, LE Smythies, LE Smythies, LE Smythies, LG Pacifico, LX Neves, M Eberl, M Gui, M Street, M Tendler, M Tian, MJ Laxer, MS Jiang, NA Moloney, P Miller, PM Knopf, PP Diniz, PS Coulson, PS Coulson, PS Coulson, PS Coulson, QD Bickle, QD Bickle, R Aitken, R Aitken, R Baluna, R DeMarco, R Ridi El, R Ridi El, R Ridi El, R Stephenson, R. Alan Wilson, RA Wilson, RA Wilson, RA Wilson, RA Wilson, RA Wilson, RA Wilson, RA Wilson, RE Ewaisha, RH Civil, S Anderson, SH Xiao, SH Xiao, SH Xiao, SH Xiao, SJ Parker-Manuel, SL James, SL James, SL James, SL James, SM Dubinett, SR Dias, SY Hsu, TA Wynn, TM Kariuki, W Yang, W Zhang, W Zhao, WG Guntheroth, William Castro-Borges, XH Li, XH Li, XH Li, Xiao-Hong Li, XM Hu, Y Waeckerle-Men, YC Zhu, YH Ho   +117 more
core   +2 more sources

Cloning and Characterisation of Schistosoma japonicum Insulin Receptors

PLoS ONE, 2010
Schistosomes depend for growth and development on host hormonal signals, which may include the insulin signalling pathway. We cloned and assessed the function of two insulin receptors from Schistosoma japonicum in order to shed light on their role in schistosome biology.We isolated, from S. japonicum, insulin receptors 1 (SjIR-1) and 2 (SjIR-2) sharing
Geoffrey N. Gobert, Wenbao Zhang, Glynn Rees, David Blair, Donald P. McManus, Klaus Brehm, Jason Mulvenna, Hong You, Malcolm K. Jones, Malcolm K. Jones, Mark D. Spanevello, Mary Duke   +11 more
openaire   +6 more sources

Imported Schistosomiasis in Southwestern Europe: Wide Variation of Pure and Hybrid Genotypes Infecting Sub‐Saharan Migrants

Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.
Mitochondrial cox1 and nuclear ribosomal ITSs are commonly combined to distinguish Schistosoma species and identify hybrids in endemic countries but very rarely applied to patients diagnosed in Europe despite the increasing arrival of migrants in southwestern Europe.
Alejandra De Elias-Escribano, Patricio Artigas, Joaquin Salas-Coronas, María Pilar Luzon-Garcia, Marta Reguera-Gomez, Raquel Sanchez-Marques, Fernando Salvador, Jerôme Boissier, Santiago Mas-Coma, Maria Dolores Bargues, Horacio Bach   +10 more
wiley   +1 more source

Histopathological Study of Wistar Rat Liver Infected with Schistosoma japonicum

WMJ (Warmadewa Medical Journal)
Schistosoma, including Schistosoma japonicum (S. japonicum), can live with an intermediate host, such as rats, and infect mammals, such as humans and rats. We can use a rat model to understand the pathophysiology of Schistosoma. The aim of this study is
David Pakaya , Varel Bramantio Gagola, Christin Rony Nayoan , Junjun Fitriani , Vera Diana Towidjojo   +4 more
doaj   +1 more source

Western Anthelmintics in Early Twentieth‐Century China Colonial Practices and Knowledge on “Tropical Diseases” of the In/between**

Berichte zur Wissenschaftsgeschichte, Volume 47, Issue 4, Page 330-351, December 2024.
Abstract Protestant (medical) missionaries were the main proponents of Western medicine in China after the Opium Wars. Several studies have highlighted how they used spectacular surgery as a means of gaining public trust. As well as surgery, they also administered anthelmintic drugs such as santonin as a tool of persuasion and conversion.
Dominik Merdes
wiley   +1 more source

Release of extracellular vesicles containing small RNAs from the eggs of Schistosoma japonicum

Parasites & Vectors, 2016
Background Schistosoma japonicum is a parasitic flatworm that causes human schistosomiasis. Secreted extracellular vesicles (EVs) play a key role in pathogen-host interfaces. Previous studies have shown that S. japonicum adult worms can release microRNA (
Shanli Zhu, Sai Wang, Yu Lin, Pengyue Jiang, Xiaobin Cui, Xinye Wang, Yuanbin Zhang, Weiqing Pan   +7 more
doaj   +1 more source