Results 121 to 130 of about 65,479 (293)

Schistosoma japonicum infection causes a reprogramming of glycolipid metabolism in the liver

Parasites & Vectors, 2019
Recent investigations indicate that schistosome infection is closely associated with aberrant glycolipid metabolism. However, the actual glycolipid metabolism gene expression, as well as the possible pathways that regulate glycolipid metabolism in the ...
Zhipeng Xu, Hao Chang, Yangyue Ni, Chen Li, Lin Chen, M. Hou, M. Ji   +6 more
semanticscholar   +1 more source

Photodynamic therapy of cancer‐associated infections

Photochemistry and Photobiology, Volume 101, Issue 4, Page 833-845, July/August 2025.
Pathogens can be involved in tumor initiation, promotion and progression through different mechanisms, and their treatment can prevent new cancer cases, improve outcomes, and revert poor‐prognostic phenotypes. Photodynamic therapy (PDT) successfully treats different types of cancers and infections, and, therefore, has a unique potential to address ...
Giulia Kassab, Juan Chen, Gang Zheng
wiley   +1 more source

In vivo and in vitro activity of oil extract of garlic (Allium sativum Linnaeus) against Schistosoma japonicum cercariae

Revista da Sociedade Brasileira de Medicina Tropical
: INTRODUCTION: The activity of garlic oil extract against Schistosoma japonicum cercariae was evaluated. METHODS: The in vitro and in vivo cercaricidal activities against S. japonicum larvae were determined. RESULTS: Exposure to ≥ 10-6 (v/v) garlic
Kang Wan, Peng Wang, Leibo Zhang
doaj   +1 more source

Gastrointestinal Neoplasia Associated with Bowel Parasitosis: Real or Imaginary?

Journal of Tropical Medicine, 2011
Several parasitic species are well known to have carcinogenic properties, namely; Schistosoma hematobium (squamous cell carcinoma of the bladder) and the liver flukes Opisthorchis and Chlonorchis (cholangiocarcinoma).
Michael R. Peterson, Noel Weidner
doaj   +1 more source

Comparative Study of Transcriptome Profiles of Mouse Livers and Skins Infected by Fork-Tailed or Non-Fork-Tailed Schistosoma japonicum

Frontiers in Microbiology, 2017
Schistosoma japonicum (S. japonicum) is a worldwide spread pathogen which penetrates host skin and then induces several diseases in infected host, such as fibrosis, formation of granulomas, hepatocirrhosis, and hepatomegaly.
Yan Yang, Jun-Jun He, Shuang Hu, Hua Chang, Xun Xiang, Jian-Fa Yang, Feng-Cai Zou   +6 more
doaj   +1 more source

β-Actin: Not a Suitable Internal Control of Hepatic Fibrosis Caused by Schistosoma japonicum

Frontiers in Microbiology, 2019
Schistosomiasis japonica is a significant health problem that leads to morbidity and mortality of humans. It is characterized by hepatic granulomatous response and fibrosis caused by eggs deposition in the liver. β-actin, a traditional housekeeping gene,
Bei-bei Zhang, Xiaoying Wu, Jiahua Liu, Lan-gui Song, Qiuyue Song, Lifu Wang, Dongjuan Yuan, Zhongdao Wu   +7 more
semanticscholar   +1 more source

Enhancing schistosomiasis drug discovery approaches with optimized proteasome substrates

Protein Science, Volume 34, Issue 6, June 2025.
Abstract Schistosomiasis, a neglected tropical disease infecting over 200 million people globally, has limited therapeutic options. The 20S proteasome is a validated drug target for many parasitic infections, including those caused by Plasmodium and Leishmania, and we have previously demonstrated antischistosomal activity with inhibitors targeting ...
Elany B. Silva, Zhenze Jiang, Chenxi Liu, Pavla Fajtová, Thaiz R. Teixeira, Giovana de Castro Fiorini Maia, Lawrence J. Liu, Nelly El‐Sakkary, Danielle E. Skinner, Ali Syed, Steven C Wang, Conor R. Caffrey, Anthony J. O'Donoghue   +12 more
wiley   +1 more source

Soluble egg antigen of Schistosoma japonicum induces pyroptosis in hepatic stellate cells by modulating ROS production

Parasites & Vectors, 2019
Inflammation-induced dysfunction of hepatic stellate cells (HSCs) is involved in schistosomiasis-associated liver fibrosis, and soluble egg antigen (SEA) is a crucial pathogen-associated molecular pattern associated with liver injury in schistosomiasis ...
Delong Kong, Fanyun Kong, X. Liu, Chao Yan, Jie Cui, R. Tang, K. Zheng   +6 more
semanticscholar   +1 more source

Analysis of miR‐10a and IFNG Expression Before and After Treatment for Chronic Schistosomiasis mansoni

Parasite Immunology, Volume 47, Issue 6, June 2025.
ABSTRACT Mir‐10a acts in signalling pathways regulating transcription, translation, and RNA‐mediated gene silencing, while IFNG acts in the T‐cell receptor signalling pathway. Thus, both can be considered potential targets for understanding regulatory processes in chronic inflammation in patients with schistosomiasis.
Débora Nascimento da Nóbrega, Ana Virgínia Matos Sá Barreto, Roberta dos Santos Souza, Kleyton Palmeira do Ó, Raul Emídio de Lima, Ana Lúcia Coutinho Domingues, Edmundo Pessoa Lopes, Clarice Neuenschwander Lins de Morais, Elainne Christine de Souza Gomes, Luydson Richardson Silva Vasconcelos   +9 more
wiley   +1 more source

Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection

Cells, 2019
Background: Schistosomiasis is an immunopathogenic disease in which Th17 cells play vital roles. Hepatic granuloma formation and subsequent fibrosis are its main pathologic manifestations and the leading causes of hepatic cirrhosis, and effective ...
W. Zhou, Yingying Yang, C. Mei, Panpan Dong, S. Mu, Hongchu Wu, Yonghua Zhou, Yi Zheng, F. Guo, Jun-Qi Yang   +9 more
semanticscholar   +1 more source