Results 121 to 130 of about 64,179 (295)

Targeting Fibrosis: From Molecular Mechanisms to Advanced Therapies

Advanced Science, Volume 12, Issue 3, January 20, 2025.
This review comprehensively summarizes the advances in research for fibrosis. It emphasizes organ‐specific profibrotic cell types and molecular mechanisms of fibrosis, especially in the kidney, liver, lung, and heart. The authors highlight the advanced antifibrotic small molecule drugs and cellular therapies for fibrosis.
Xingpeng Di, Ya Li, Jingwen Wei, Tianyue Li, Banghua Liao   +4 more
wiley   +1 more source

Parasite-derived circulating microRNAs as biomarkers for the detection of human Schistosoma japonicum infection

Parasitology, 2019
Novel tools for early diagnosis and monitoring of schistosomiasis are urgently needed. This study aimed to validate parasite-derived miRNAs as potential novel biomarkers for the detection of human Schistosoma japonicum infection.
Y. Mu, Pengfei Cai, R. Olveda, Allen G P Ross, David U. Olveda, D. McManus   +5 more
semanticscholar   +1 more source

Tissue‐resident memory T cells in diseases and therapeutic strategies

MedComm, Volume 6, Issue 1, January 2025.
Tissue‐resident memory T (TRM) cells are crucial components of the immune system and play vital roles in antiviral, antibacterial, and antitumor immunity, as well as chronic inflammation conditions and graft‐versus‐host diseases. Understanding the intricate regulation of TRM cells is crucial for developing targeted therapeutic strategies, such as ...
Daoyuan Xie, Guanting Lu, Gang Mai, Qiuyan Guo, Guofeng Xu   +4 more
wiley   +1 more source

High-throughput sequencing of RNAs isolated by cross-linking immunoprecipitation (HITS-CLIP) reveals Argonaute-associated microRNAs and targets in Schistosoma japonicum [PDF]

, 2015
Sequences of SjAgo-associated novel miRNAs by the HITS-CLIP assay.
Jing Zhao, Qingfeng Zhang, Rong Luo, Weiqing Pan, Xindong Xu, Ying Zou   +5 more
core   +8 more sources

Identification and validation of a Schistosoma japonicum U6 promoter

Parasites & Vectors, 2017
Background RNA polymerase III promoters have been widely used to express short hairpin-RNA (shRNA), microRNA (miRNA), and small guide RNA (sgRNA) in gene functional analysis in a variety of organisms including Schistosoma mansoni.
Qing Li, Wan Wang, Nan Zhao, Pengcheng Li, Yue Xin, Wei Hu   +5 more
doaj   +1 more source

Schistosoma japonicum peptide SJMHE1 suppresses airway inflammation of allergic asthma in mice

Journal of Cellular and Molecular Medicine, 2019
Helminths and their products can shape immune responses by modulating immune cells, which are dysfunctional in inflammatory diseases such as asthma. We previously identified SJMHE1, a small molecule peptide from the HSP60 protein of Schistosoma japonicum.
Wenzhe Zhang, Li Li, Y. Zheng, F-B Xue, Mengzhu Yu, Yongbin Ma, Liyang Dong, Zirui Shan, Dingqi Feng, Ting Wang, Xuefeng Wang   +10 more
semanticscholar   +1 more source

How Do Trematodes Induce Cancer? A Possible Evolutionary Adaptation of an Oncogenic Agent Transmitted by Flukes

Evolutionary Applications, Volume 18, Issue 1, January 2025.
ABSTRACT There is strong epidemiological evidence that development of various cancer types is linked to infection with flukes (Platyhelminthes: Trematoda) in Africa, Asia and the Middle East. The exact nature of the mechanism by which cancer is induced by these parasites is unknown.
Péter Apari, Gábor Földvári
wiley   +1 more source

Do schistosome vaccine trials in mice have an intrinsic flaw that generates spurious protection data? [PDF]

, 2016
The laboratory mouse has been widely used to test the efficacy of schistosome vaccines and a long list of candidates has emerged from this work, many of them abundant internal proteins.
A Dessein, AP Mountford, AP Mountford, AV Wisnewski, AW Cheever, B Nare, BC Figueiredo, BL Mangold, BL Mangold, C Carvalho-Queiroz, CC Alves, CC Tang, CL Sokol, CS Pinheiro, CX Yu, D Boulanger, D Lin, D Moser, DA Dean, DA Dean, DA Dean, DA Vignali, DS Yole, DS Yole, DW Dunne, E Long, EC Ratcliffe, EJ Pearce, EK Birks, FC Cardoso, G Ahmad, GS Philippsen, GV Hillyer, GV Hillyer, H Chen, IW Chalmers, J Yu, JB West, JE Crabtree, JE Crabtree, JE Crabtree, JE Portielje, JL Abane, JL Yu, JP Hewitson, KD Murrell, KS Warren, KY Park, L Argiro, LA Soisson, LE Smythies, LE Smythies, LE Smythies, LG Pacifico, LX Neves, M Eberl, M Gui, M Street, M Tendler, M Tian, MJ Laxer, MS Jiang, NA Moloney, P Miller, PM Knopf, PP Diniz, PS Coulson, PS Coulson, PS Coulson, PS Coulson, QD Bickle, QD Bickle, R Aitken, R Aitken, R Baluna, R DeMarco, R Ridi El, R Ridi El, R Ridi El, R Stephenson, R. Alan Wilson, RA Wilson, RA Wilson, RA Wilson, RA Wilson, RA Wilson, RA Wilson, RA Wilson, RE Ewaisha, RH Civil, S Anderson, SH Xiao, SH Xiao, SH Xiao, SH Xiao, SJ Parker-Manuel, SL James, SL James, SL James, SL James, SM Dubinett, SR Dias, SY Hsu, TA Wynn, TM Kariuki, W Yang, W Zhang, W Zhao, WG Guntheroth, William Castro-Borges, XH Li, XH Li, XH Li, Xiao-Hong Li, XM Hu, Y Waeckerle-Men, YC Zhu, YH Ho   +117 more
core   +2 more sources

Therapeutic efficacy of Schistosoma japonicum cystatin on sepsis-induced cardiomyopathy in a mouse model

Parasites & Vectors, 2019
Myocardial dysfunction is one of the most common complications of multiple organ failure in septic shock and significantly increases mortality in patients with sepsis.
Shifang Gao, Huihui Li, H. Xie, Shili Wu, Yuan Yuan, L. Chu, Si Sun, Huijuan Yang, Lingqing Wu, Yongsheng Bai, Qiao-mei Zhou, Xin Wang, B. Zhan, Huafeng Cui, Xiaodi Yang   +14 more
semanticscholar   +1 more source

Cloning and Characterisation of Schistosoma japonicum Insulin Receptors

PLoS ONE, 2010
Schistosomes depend for growth and development on host hormonal signals, which may include the insulin signalling pathway. We cloned and assessed the function of two insulin receptors from Schistosoma japonicum in order to shed light on their role in schistosome biology.We isolated, from S. japonicum, insulin receptors 1 (SjIR-1) and 2 (SjIR-2) sharing
Geoffrey N. Gobert, Wenbao Zhang, Glynn Rees, David Blair, Donald P. McManus, Klaus Brehm, Jason Mulvenna, Hong You, Malcolm K. Jones, Malcolm K. Jones, Mark D. Spanevello, Mary Duke   +11 more
openaire   +6 more sources