Results 141 to 150 of about 65,479 (293)

Histopathological Study of Wistar Rat Liver Infected with Schistosoma japonicum

WMJ (Warmadewa Medical Journal)
Schistosoma, including Schistosoma japonicum (S. japonicum), can live with an intermediate host, such as rats, and infect mammals, such as humans and rats. We can use a rat model to understand the pathophysiology of Schistosoma. The aim of this study is
David Pakaya , Varel Bramantio Gagola, Christin Rony Nayoan , Junjun Fitriani , Vera Diana Towidjojo   +4 more
doaj   +1 more source

Release of extracellular vesicles containing small RNAs from the eggs of Schistosoma japonicum

Parasites & Vectors, 2016
Background Schistosoma japonicum is a parasitic flatworm that causes human schistosomiasis. Secreted extracellular vesicles (EVs) play a key role in pathogen-host interfaces. Previous studies have shown that S. japonicum adult worms can release microRNA (
Shanli Zhu, Sai Wang, Yu Lin, Pengyue Jiang, Xiaobin Cui, Xinye Wang, Yuanbin Zhang, Weiqing Pan   +7 more
doaj   +1 more source

Non-coding RNAs in schistosomes: an unexplored world [PDF]

, 2011
Non-coding RNAs (ncRNAs) were recently given much higher attention due to technical advances in sequencing which expanded the characterization of transcriptomes in different organisms. ncRNAs have different lengths (22 nt to >1, 000 nt) and mechanisms of
CARVALHO, Mariana L. P, KITAJIMA, João P, MARACAJA-COUTINHO, Vinicius, OLIVEIRA, Katia C, VERJOVSKI-ALMEIDA, Sergio   +4 more
core   +2 more sources

Therapeutic efficacy of Schistosoma japonicum cystatin on sepsis-induced cardiomyopathy in a mouse model

Parasites & Vectors, 2019
Myocardial dysfunction is one of the most common complications of multiple organ failure in septic shock and significantly increases mortality in patients with sepsis.
Shifang Gao, Huihui Li, H. Xie, Shili Wu, Yuan Yuan, L. Chu, Si Sun, Huijuan Yang, Lingqing Wu, Yongsheng Bai, Qiao-mei Zhou, Xin Wang, B. Zhan, Huafeng Cui, Xiaodi Yang   +14 more
semanticscholar   +1 more source

Cellular and humoral immune responses and protection against schistosomes induced by a radiation-attenuated vaccine in chimpanzees [PDF]

, 2001
The radiation-attenuated Schistosoma mansoni vaccine is highly effective in rodents and primates but has never been tested in humans, primarily for safety reasons.
Abe K., Agnew A., Amory Soisson L., Aranda-Michel J., Araújo M. I., Ashton P. D., Bergquist N. R., Butterworth A. E., Butterworth A. E., Caldas I. R., Capron A., Carneiro-Santos P., Caulada-Benedetti Z., Chan M. S., Coulson P. S., de Clercq D., de Jonge N., Deelder A. M., Doetze A., Dunne D. W., Eberl M., Eberl M., Eberl M., Gryseels B, Gryseels B., Grzych J. M., Harrop R., Harrop R., Hsü S. Y., Jankovic D., Kardorff R., Kasper G., Katz N., Kuntz R. E., Mahmoud O. M., Malaquias L. C. C., Mansour M. M., Marguerite M., Medhat A., Montenegro S. M. L., Moser D., Olsen A., Omer F. M., Omer-Ali P., Pearce E. J., Pemberton R. M., Polman K., Prince A. M., Renquist D. M., Rieckmann K. H., Rocha M. O., Sadun E. H., Sadun E. H., Sher A., Smythies L. E., Sundstedt A., Tanner M., Velupillai P., Viana I. R., Viana I. R., von Lichtenberg F., von Lichtenberg F., Williams M. E., Wilson R. A., Yole D. S., Yole D. S.   +65 more
core   +2 more sources

Interleukin‐9 blockage reduces early hepatic granuloma formation and fibrosis during Schistosoma japonicum infection in mice

Immunology, 2019
Hepatic fibrosis induced by schistosomes is regulated by a complex network of cytokines. T helper type 9 (Th9) cells are a new type of effector T helper cells, which mainly secrete the specific cytokine interleukin‐9 (IL‐9).
Ting-zheng Zhan, Huihui Ma, Suqin Jiang, Zirong Zhong, Xiaoli Wang, Chunxiang Li, Dan Yu, Lei Liu, Jing Xu, C. Xia   +9 more
semanticscholar   +1 more source

Expression of TLR2, TLR3, TLR4, and TLR7 on pulmonary lymphocytes of Schistosoma japonicum-infected C57BL/6 mice

Innate Immunity, 2019
Despite the paramount role of TLRs in the induction of innate immune and inflammatory responses, there is a paucity of studies on the role of TLRs in Schistosoma japonicum infection.
Dianhui Chen, Yi Zhao, Yuanfa Feng, Chenxi Jin, Quan Yang, Huaina Qiu, Hongyan Xie, S. Xie, Yi Zhou, Jun Huang   +9 more
semanticscholar   +1 more source

B1 cells protect against Schistosoma japonicum–induced liver inflammation and fibrosis by controlling monocyte infiltration

PLoS Neglected Tropical Diseases, 2019
During Schistosoma infection, lack of B cells results in more severe granulomas, inflammation, and fibrosis in the liver, but the mechanisms underlying this pathology remain unclear.
Liang Yong, Yuanyuan Tang, Cui-ping Ren, Miao Liu, Ji-jia Shen, Xin Hou   +5 more
semanticscholar   +1 more source

Schistosome serine protease inhibitors: parasite defense or homeostasis?

Anais da Academia Brasileira de Ciências, 2011
Serpins are a structurally conserved family of macromolecular inhibitors found in numerous biological systems. The completion and annotation of the genomes of Schistosoma mansoni and Schistosoma japonicum has enabled the identification by phylogenetic ...
Landys A. Lopez Quezada, James H McKerrow   +1 more
doaj   +1 more source

C/EBP Homologous Protein (CHOP) Activates Macrophages and Promotes Liver Fibrosis in Schistosoma japonicum-Infected Mice

Journal of Immunological Research, 2019
CCAAT/enhancer-binding homologous protein (CHOP), a transcriptional regulator induced by endoplasmic reticulum stress (ER stress) is a pivotal factor in the ER stress-mediated apoptosis pathway.
M. Duan, Yuan Yang, Shuang Peng, Xiaoqin Liu, Jixin Zhong, Yurong Guo, Min Lu, Hao Nie, Boxu Ren, Xiangzhi Zhang, Lian Liu   +10 more
semanticscholar   +1 more source