Results 61 to 70 of about 65,479 (293)

Deficiency of PKCλ/ι alleviates the liver pathologic impairment of Schistosoma japonicum infection by thwarting Th2 response

Parasites & Vectors, 2022
Background The activation of immune response driven by the eggs of Schistosoma japonicum and the subsequent secretions is the culprit behind granulomatous inflammation and liver fibrosis.
Congjin Mei, Yingying Yang, Panpan Dong, Lijun Song, Yonghua Zhou, Yongliang Xu, Chuanxin Yu   +6 more
doaj   +1 more source

Fragment-based discovery of a regulatory site in thioredoxin glutathione reductase acting as "doorstop" for NADPH entry [PDF]

, 2018
Members of the FAD/NAD-linked reductase family are recognized as crucial targets in drug development for cancers, inflammatory disorders, and infectious diseases.
Angelucci, Francesco, Ardini, Matteo, Arner, Elias S. J., Bellelli, Andrea, Boumis, Giovanna, Chen, Qing, Fata, Francesca, Ippoliti, Rodolfo, Jadhav, Ajit, Lea, Wendy A., Lyu, Haining, Miele, Adriana E., Petukhov, Pavel A., Silvestri, Ilaria, Simeonov, Anton, Thatcher, Gregory R. J., Williams, David L.   +16 more
core   +4 more sources

Analysis and characterization of the genes encoding the Dicer and Argonaute proteins of Schistosoma japonicum

Parasites & Vectors, 2010
Background The Dicer and Argonaute(AGO) proteins within the small RNA regulatory pathways (SRRPs) play an indispensable role in regulation of gene expression.
Sun Jun, Wang Zhangxun, Xue Xiangyang, Luo Rong, Zou Ying, Pan Weiqing   +5 more
doaj   +1 more source

Schistosoma japonicum cathepsin B2 (SjCB2) facilitates parasite invasion through the skin

PLoS Neglected Tropical Diseases, 2020
Cercariae invasion of the human skin is the first step in schistosome infection. Proteases play key roles in this process. However, little is known about the related hydrolytic enzymes in Schistosoma japonicum.
B. Zhu, F. Luo, Yi Shen, Wenbin Yang, Cheng-song Sun, Jipeng Wang, Jian Li, X. Mo, Bin Xu, Xumin Zhang, Yongdong Li, Wei Hu   +11 more
semanticscholar   +1 more source

The inhibitory effect against collagen-induced arthritis by Schistosoma japonicum infection is infection stage-dependent

BMC Immunology, 2010
Background A long-term existing schistosome infection can aid in maintaining immuno-homeostasis, thus providing protection against various types of autoimmune diseases to the infected host. Such benefits have often been associated with acute or egg stage
Chi FengLi, Li Jun, Chen ChunXia, Yin Lan, Zhuang WenJia, Li Jia, He YunKun, Bai YanShuang, Chen Xiao-Ping   +8 more
doaj   +1 more source

Gut microbiota signatures in Schistosoma japonicum infection-induced liver cirrhosis patients: a case–control study

Infectious Diseases of Poverty, 2020
Background Several studies have assessed the role of gut microbiota in various cirrhosis etiologies, however, none has done so in the context of Schistosoma japonicum infection in humans.
Qifeng Gui, Hui-Lin Jin, Feng Zhu, H. Lu, Qin Zhang, Jia Xu, Yunmei Yang, C. Xiao   +7 more
semanticscholar   +1 more source

Hybridisations within the genus Schistosoma: implications for evolution, epidemiology and control [PDF]

, 2016
SUMMARYHybridization of parasites is an emerging public health concern in our changing world. Hybridization and introgression in parasites and pathogens can have major impacts on the host and the epidemiology and evolution of disease.
Leger, E, Webster, J P
core   +2 more sources

SjTat-TPI facilitates adaptive T-cell responses and reduces hepatic pathology during Schistosoma japonicum infection in BALB/c mice

Parasites & Vectors, 2015
Background Schistosomiasis is a kind of parasitic zoonoses which causes serious damage to public health and social development. China is one of the countries most affected by Schistosoma japonicum and an effective vaccine is still needed.
Wenyue Zhang, Xiaofeng Luo, Fan Zhang, Yuxiao Zhu, Bingya Yang, Min Hou, Zhipeng Xu, Chuanxin Yu, Yingying Chen, Lin Chen, Minjun Ji   +10 more
doaj   +1 more source

The genetic variation of different developmental stages of Schistosoma japonicum: do the distribution in snails and pairing preference benefit the transmission?

Parasites & Vectors, 2020
Background Schistosoma japonicum is a waterborne parasite that causes schistosomiasis in humans and in more than 40 animal species. Schistosoma japonicum shows distinct genetic differentiation among geographical populations and multiple hosts, but the ...
Meng-Jie Gu, Yan-Wei Li, Aidan M. Emery, Shi-Zhu Li, Yong-Zhong Jiang, Hui-Fen Dong, Qin-Ping Zhao   +6 more
doaj   +1 more source

Galectins, Eosinophiles, and Macrophages May Contribute to Schistosoma japonicum Egg-Induced Immunopathology in a Mouse Model

Frontiers in Immunology, 2020
Schistosomiasis is a severe public health problem, which can cause tissue fibrosis and can even be fatal. Previous studies have proven that galectins and different kinds of cells involve in the regulation of tissue fibrosis process.
Zhanhong Ye, Shiguang Huang, Yanxia Zhang, Xu Mei, Huanqin Zheng, Meiyu Li, Jianhuang Chen, Fangli Lu   +7 more
semanticscholar   +1 more source