Schistosoma mansoni: Insulin independence
Several authors have reported that schistosomes are affected by host hormones, including insulin. We found that insulin in a 10,000-fold range of concentrations failed to affect glucose consumption of males, females, or pairs of Schistosoma mansoni incubated for periods up to 24 hr.
Paul F. Basch, L.Edward Clemens
openaire +3 more sources
Co-infections with Plasmodium falciparum, Schistosoma mansoni and intestinal helminths among schoolchildren in endemic areas of northwestern Tanzania. [PDF]
Malaria, schistosomiasis and intestinal helminth infections are causes of high morbidity in most tropical parts of the world. Even though these infections often co-exist, most studies focus on individual diseases.
Heukelbach, Jorg+11 more
core +5 more sources
Point of Care Diagnosis of Multiple Schistosome Parasites: Species-specific DNA Detection in Urine by Loop-mediated Isothermal Amplification (LAMP) [PDF]
Schistosomes are easily transmitted and high chance of repeat infection, so if control strategies based on targeted mass drug administration (MDA) are to succeed it is essential to have a test that is sensitive, accurate and simple to use.
Anyan, William K.+6 more
core +2 more sources
Schistosome serine protease inhibitors: parasite defense or homeostasis?
Serpins are a structurally conserved family of macromolecular inhibitors found in numerous biological systems. The completion and annotation of the genomes of Schistosoma mansoni and Schistosoma japonicum has enabled the identification by phylogenetic ...
Landys A. Lopez Quezada+1 more
doaj +1 more source
Experimental schistosomiasis in the Common Marmoset Callithrix jacchus
In order to evaluate Callithrix jacchus as an animal model for mansoni schistosomiasis, a group of 10 male animals were once percutaneously exposed to 250 cercariae of the Schistosoma mansoni SLM (São Lourenço da Mata) strain.
Ana Luna de Oliveira+4 more
doaj
In the absence of CD154, administration of interleukin-12 restores Th1 responses but not protective immunity to Schistosoma mansoni [PDF]
The cytokine interplay during the development of protective immunity to the radiation-attenuated (RA) schistosome vaccine has been extensively characterized over recent years, yet the role of costimulatory molecules in the development of cell-mediated ...
Hamblin, Paul A+2 more
core +2 more sources
The Role of Type 2 Inflammation in Schistosoma-Induced Pulmonary Hypertension
Approximately 5% of individuals chronically infected with Schistosoma mansoni develop pulmonary hypertension (PH). The disease is progressive and often fatal, and treatment options are palliative, not curative. Recent studies have unraveled major players
Claudia S. Mickael, Brian B. Graham
doaj +1 more source
Mouse model of Schistosomiasis: infection with Schistosoma mansoni in CD-1 mice [PDF]
Schistosomiasis is a parasitic disease that affects almost 240 million worldwide. CD1 mice were infected with cercariae of S. mansoni, after which infection developed for 8 weeks. Tissues were processed to immuno-histological techniques.
Botelho, M.+3 more
core
Environmental Epidemiology of Intestinal Schistosomiasis in Uganda: Population Dynamics of Biomphalaria (Gastropoda: Planorbidae) in Lake Albert and Lake Victoria with Observations on Natural Infections with Digenetic Trematodes [PDF]
This study documented the population dynamics of Biomphalaria and associated natural infections with digenetic trematodes, along the shores of Lake Albert and Lake Victoria, recording local physicochemical factors. Over a two-and-a-half-year study period
Betson, M+5 more
core +4 more sources
Background: Malaria and schistosomiasis are two parasite illnesses that share transmission sites in distinct tropical climates. Malaria-schistosomiasis coinfection is widespread in Africa.
Wagaw Abebe+9 more
doaj