Results 101 to 110 of about 96,030 (249)

Ursolic acid ameliorates CCl4‐induced liver fibrosis through the NOXs/ROS pathway

Journal of Cellular Physiology, Volume 233, Issue 10, Page 6799-6813, October 2018., 2018
UA induces the proliferation of HCs, promotes the apoptosis of HSCs, and prevents the activation of KCs in vivo by reducing the expression of NOXs/ROS in HCs, HSCs, KCs. UA also partly improves phagocytosis of KCs and has no effect on host defense function. Liver fibrosis is a reversible wound‐healing response that occurs after liver injury.
Dakai Gan, Wang Zhang, Chenkai Huang, Jiang Chen, Wenhua He, Anjiang Wang, Bimin Li, Xuan Zhu   +7 more
wiley   +1 more source

Gut Microbiota Modulates Intestinal Pathological Injury in Schistosoma japonicum-Infected Mice

Frontiers in Medicine, 2020
Trapping of Schistosoma japonicum (S. japonicum) eggs in host tissue, mainly in the intestine and liver, causes severe gastrointestinal and hepatic granulomatous immune responses and irreversible fibrosis. Although the gut microbiota plays a central role
Beibei Zhang, Beibei Zhang, Beibei Zhang, Beibei Zhang, Beibei Zhang, Xiaoying Wu, Qiuyue Song, Qiuyue Song, Qiuyue Song, An Ning, Jinyi Liang, Jinyi Liang, Jinyi Liang, Langui Song, Langui Song, Langui Song, Jiahua Liu, Jiahua Liu, Jiahua Liu, Yishu Zhang, Dongjuan Yuan, Xi Sun, Xi Sun, Xi Sun, Zhongdao Wu, Zhongdao Wu, Zhongdao Wu   +26 more
doaj   +1 more source

Identification of a linear B-cell epitope on the Schistosoma japonicum saposin protein, SjSAP4: Potential as a component of a multi-epitope diagnostic assay.

PLoS Neglected Tropical Diseases, 2022
BackgroundSchistosoma japonicum is one of three major species of blood flukes causing schistosomiasis, a disease, which continues to be a major public health issue in the Philippines.
Yi Mu, Catherine A Gordon, Remigio M Olveda, Allen G Ross, David U Olveda, Jessica M Marsh, Donald P McManus, Pengfei Cai   +7 more
doaj   +1 more source

The basic reproductive ratio of Barbour's two-host schistosomiasis model with seasonal fluctuations [PDF]

, 2017
Motivated by the first mathematical model for schistosomiasis proposed by Macdonald and Barbour's classical schistosomiasis model tracking the dynamics of infected human population and infected snail hosts in a community, in our previous study, we ...
Cao, Hua-Hua, Gao, Shu-Jing, He, Yu-Ying, Liu, Yu-Jiang, Yang, Guo-Jing, Zhang, Xiang-Yu, Zhou, Xiao-Nong   +6 more
core   +2 more sources

Acute Appendicitis Secondary to Intestinal Schistosomiasis

Case Reports in Surgery, Volume 2025, Issue 1, 2025.
Schistosomiasis is a parasitic disease caused by blood flukes commonly found in sub‐Saharan Africa and select other areas in Asia and the Americas. The disease can manifest in a wide range of acute and chronic conditions, rarely presenting as acute appendicitis.
Ethan Shyu, Luis Arias-Espinosa, Gabriele Barrocas, Scott Weisenberg, Flavio Malcher, Paola De Nardi   +5 more
wiley   +1 more source

IL‐7 suppresses macrophage autophagy and promotes liver pathology in Schistosoma japonicum‐infected mice

Journal of Cellular and Molecular Medicine, Volume 22, Issue 7, Page 3353-3363, July 2018., 2018
Abstract In schistosomiasis japonica and mansoni, parasite eggs trapped in host liver elicit severe liver granulomatous inflammation that subsequently leads to periportal fibrosis, portal hypertension, haemorrhage or even death. Macrophages are critical for granuloma formation and the development of liver fibrosis during schistosomiasis.
Jifeng Zhu, Weiwei Zhang, Lina Zhang, Lei Xu, Xiaojun Chen, Sha Zhou, Zhipeng Xu, Ming Xiao, Hui Bai, Feng Liu, Chuan Su   +10 more
wiley   +1 more source

Schistosomiasis Chemotherapy, Chemoprevention, and Vaccines: History, Progress, and Priorities

Immunity, Inflammation and Disease, Volume 12, Issue 11, November 2024.
Schistosomiasis is a major human disease of public health importance. The goal is to provide an overview of the history and advancements in schistosomiasis chemotherapy, chemoprevention, and vaccine research. Praziquantel is effective against all species of schistosomiasis, but schistosomiasis prevalence has largely remained unaffected, due to ...
Alaa Oqalaa E. Alibrahim, Walaa A. Elkholy, Mona M. El‐Derbawy, Noha F. Zahran, Athanasios Alexiou, Marios Papadakis, Gaber El‐Saber Batiha   +6 more
wiley   +1 more source

Multi-omics analyses of Bacillus amyloliquefaciens treated mice infected with Schistosoma japonicum reveal dynamics change of intestinal microbiome and its associations with host metabolism.

PLoS Neglected Tropical Diseases
BackgroundSchistosomiasis japonica is a serious threat to human health. It causes damage to the intestine and liver. Probiotic therapy has been shown to be effective in alleviating intestinal diseases and improving host health.
Hao Chen, Shuaiqin Huang, Siqi Yao, Jingyan Wang, Jing Huang, Zheng Yu   +5 more
doaj   +1 more source

Short-Term Efficacy of Laparoscopic Treatment for Colorectal Cancer in Patients with Schistosomiasis Japonica

Gastroenterology Research and Practice, 2016
Introduction. Schistosomiasis is associated with numerous complications such as thrombocytopenia, liver cirrhosis, portal hypertension, and colitis. To the best of our knowledge, the feasibility and outcomes of laparoscopic colorectal surgery in patients
Zhu Yi, Jiang Hong-Gang, Chen Zhi-Heng, Lu Bo-Hao   +3 more
doaj   +1 more source

Parasite‐derived microRNA let‐7‐5p detection for metacestodiasis based on rolling circular amplification‐assisted CRISPR/Cas9

The FASEB Journal, Volume 38, Issue 10, 31 May 2024.
MicroRNA extraction and RCA‐assisted CRISPR/Cas9 detection. Abstract Metacestodiasis is an infectious disease caused by the larval stage of cestode parasites. This disease poses a serious health hazard to wildlife, livestock, and humans, and it incurs substantial economic losses by impacting the safety of the livestock industry, the quality of meat ...
Liqun Wang, Guiting Pu, Tingli Liu, Guoliang Chen, Hong Li, Tharheer Oluwashola Amuda, Shanling Cao, Hongbin Yan, Hong Yin, Baoquan Fu, Xuenong Luo   +10 more
wiley   +1 more source