Results 111 to 120 of about 495 (168)

New Aminoquinoline with Schistosomicidal Activity

Nature, 1967
DURING routine testing of compounds, we have discovered schistosomicidal activity in a series of 5-aminoquinolines. Many compounds with this general formula were made and tested and some were found to have activity, but one compound was outstanding. This was 6-chloro-5-β-diethylaminoethylamino-8-methylquinoline.
N W, Bristow, B, Lessel, H C, Richards, G A, Williams   +3 more
openaire   +2 more sources

Synthetic schistosomicides. X. Bis(4-arylazo-1-naphthylamines)

Journal of Medicinal Chemistry, 1968
Edward F. Elslager, David B. Capps, Dianne H. Kurtz, Donald F. Worth   +3 more
openalex   +3 more sources

Potent Schistosomicidal Constituents from Garcinia brasiliensis

Planta Medica, 2015
Praziquantel is the drug of choice for the treatment of schistosomiasis. However, several strains of Schistosoma mansoni are resistant to praziquantel, making it necessary to discover new drugs that might be used for its treatment. With this in mind, the properties of a schistosomicidal ethanolic extract of Garcinia brasiliensis Mart.
Aline Pereira, Castro, Ana Carolina Alves, de Mattos, Neusa Araújo, Pereira, Naira Ferreira, Anchieta, Matheus Siqueira, Silva, Danielle Ferreira, Dias, Claudinei Alves, Silva, Giulliano Vilela, Barros, Raquel Lopes Martins, Souza, Marcelo Henrique, Dos Santos, Marcos José, Marques   +10 more
openaire   +2 more sources

Furofuran lignans display schistosomicidal and trypanocidal activities

Phytochemistry, 2014
Parasitic diseases continue to be a major worldwide health problem, and there is an urgent need for development of therapeutic drugs. This paper describes synthesis of dehydrodiferulic acid dilactone 1 and dehydrodisinapic acid dilactone 2 furofuran lignans by oxidative coupling of ferulic and sinapic acids, respectively.
Ana Carolina, Pereira, Viviane Rodrigues, Esperandim, Daniele, Ferreira da Silva, Daniele da Silva, Ferreira, Lizandra Guidi, Magalhães, Thais Coelho, Lima, Dhammika N P, Nanayakkara, Wilson Roberto, Cunha, Jairo Kenupp, Bastos, Márcio Luis, Andrade e Silva   +9 more
openaire   +2 more sources

Laboratory evaluation of schistosomicidal substances

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1967
Abstract The broad approaches to experimental chemotherapy of schistosomiasis are reviewed and the biological principles on which assessment of drug action can be made are discussed. The type of activity required in schistosomicides can be prophylactic, egg-suppressive or curative, and the method of assessment will vary accordingly.
openaire   +2 more sources

Schistosomicidal and Antioxidant Flavonoids from Astragalus englerianus

Planta Medica, 2014
Astragalus englerianus is a close relative of the traditional Chinese medicine plant Radix Astragali (Huang-qi) and is mainly distributed in Yunnan. It has been traditionally used as a substitute of "Huang-qi" for reducing fatigue and enhancing immunity by local folks.
Chao-Jiang, Xiao, Yu, Zhang, Lin, Qiu, Xiang, Dong, Bei, Jiang   +4 more
openaire   +2 more sources

Fungal Transformation and Schistosomicidal Effects of Pimaradienoic Acid

Chemistry & Biodiversity, 2012
AbstractThe schistosomicidal effects of pimaradienoic acid (PA) and two derivatives, obtained by fungal transformation in the presence of Aspergillus ochraceus, were investigated. PA was the only compound with antischistosomal activity among the three diterpenes studied, with the ability to significantly reduce the viability of the parasites at ...
Thiago S, Porto, Ademar A, da Silva Filho, Lizandra G, Magalhães, Raquel A, dos Santos, Niege A J C, Furtado, Nilton S, Arakawa, Suraia, Said, Dionéia C R, de Oliveira, Luiz E, Gregório, Vanderlei, Rodrigues, Rodrigo C S, Veneziani, Sérgio R, Ambrósio   +11 more
openaire   +2 more sources

Schistosomicidal sesquiterpene lactone from Eremanthus elaeagnus

Phytochemistry, 1972
Abstract Eremanthine, a new guaianolide isolated from the heartwood oil of Eremanthus elaeagnus Sch. Bip., has the structure (I). It is the principal active constituent responsible for the prophylactic action of the oil against the human parasite Schistosoma mansoni .
W. Vichnewski, B. Gilbert
openaire   +1 more source

Cytochalasin D abolishes the schistosomicidal activity of praziquantel

Experimental Parasitology, 2007
To test the hypothesis that calcium channels of schistosomes are the targets for the action of praziquantel, we subjected schistosomes in vitro to pharmacological agents capable of interfering with the functioning of calcium channels. After 1-h exposure to these agents, praziquantel was added and incubation continued overnight.
PicaMattoccia L, Valle C, Basso A, Troiani AR, Vigorosi F, Liberti P, Festucci A, Cioli D   +7 more
openaire   +4 more sources

The toxicology of the schistosomicidal agent oxamniquine

Drug Development Research, 1984
AbstractOxamniquine displayed low acute toxicity in mice, hamsters, and rabbits. In rats, however, oxamniquine was much more toxic, the female being 8–10 times more sensitive than the male; single doses elicited an idiosyncratic sex‐linked hepatic necrosis and bile duct proliferation.
M. Chvédoff, J. M. Faccini, M. H. Gregory, R. M. Hull, A. M. Monro, J. Perraud, R. M. Quinton, H. H. Reinert   +7 more
openaire   +1 more source