Results 271 to 280 of about 921,979 (317)
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The Lancet, 1976
The antipsychotic actions and extra-pyramidal side-effects of neuroleptic drugs are strongly correlated with their ability to block central dopaminergic transmission. It is argued that the former are more closely related to actions on dopaminergic mechanisms in the "mesolimbic dopamine" system, and the latter to similar actions in the striatum ...
Eve C. Johnstone +7 more
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The antipsychotic actions and extra-pyramidal side-effects of neuroleptic drugs are strongly correlated with their ability to block central dopaminergic transmission. It is argued that the former are more closely related to actions on dopaminergic mechanisms in the "mesolimbic dopamine" system, and the latter to similar actions in the striatum ...
Eve C. Johnstone +7 more
openaire +12 more sources
The Lancet, 1999
Schizophrenia is among the most severe and debilitating of psychiatric disorders. Diagnosis is currently by criterion-based systems, including positive (eg, hallucinations and delusions) and negative (eg, avolition and alogia) symptoms. The importance of negative symptoms in the course and outcome of the illness is increasingly being studied.
S K, Schultz, N C, Andreasen
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Schizophrenia is among the most severe and debilitating of psychiatric disorders. Diagnosis is currently by criterion-based systems, including positive (eg, hallucinations and delusions) and negative (eg, avolition and alogia) symptoms. The importance of negative symptoms in the course and outcome of the illness is increasingly being studied.
S K, Schultz, N C, Andreasen
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Implications of normal brain development for the pathogenesis of schizophrenia.
Archives of General Psychiatry, 1987Recent research on schizophrenia has demonstrated that in this disorder the brain is not, strictly speaking, normal. The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology
D. Weinberger
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What are the functional consequences of neurocognitive deficits in schizophrenia?
American Journal of Psychiatry, 1996OBJECTIVE It has been well established that schizophrenic patients have neurocognitive deficits, but it is not known how these deficits influence the daily lives of patients. The goal of this review was to determine which, if any, neurocognitive deficits
Michael F. Green
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American Journal of Psychiatry, 2003
OBJECTIVE The clinical hallmark of schizophrenia is psychosis. The objective of this overview is to link the neurobiology (brain), the phenomenological experience (mind), and pharmacological aspects of psychosis-in-schizophrenia into a unitary framework.
S. Kapur
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OBJECTIVE The clinical hallmark of schizophrenia is psychosis. The objective of this overview is to link the neurobiology (brain), the phenomenological experience (mind), and pharmacological aspects of psychosis-in-schizophrenia into a unitary framework.
S. Kapur
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Perspectives on Psychological Science, 2008
Abstract: Schizophrenia is a major mental illness characterized by psychosis, apathy and social withdrawal, and cognitive impairment, which often results in impaired functioning in the areas of work, school, parenting, self-care, independent living, interpersonal relationships, and leisure time.
Kim T. Mueser, Shirley M. Glynn
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Abstract: Schizophrenia is a major mental illness characterized by psychosis, apathy and social withdrawal, and cognitive impairment, which often results in impaired functioning in the areas of work, school, parenting, self-care, independent living, interpersonal relationships, and leisure time.
Kim T. Mueser, Shirley M. Glynn
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Remission in schizophrenia: proposed criteria and rationale for consensus.
American Journal of Psychiatry, 2005New advances in the understanding of schizophrenia etiology, course, and treatment have increased interest on the part of patients, families, advocates, and professionals in the development of consensus-defined standards for clinical status and ...
N. Andreasen +5 more
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Aripiprazole for schizophrenia
Cochrane Database of Systematic Reviews, 2003Treatment of people with schizophrenia using older typical antipsychotic drugs such as haloperidol can be problematic. Many fail to respond to these older antipsychotics and more people experience disabling adverse effects. Aripiprazole is said to be one of a new generation of atypical antipsychotics with good antipsychotic properties and minimal ...
Hany George El-Sayeh, Carla Morganti
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Alexithymia and Schizophrenias
Psychopathology, 1995The purpose of this study is to verify whether an increasing degree of alexithymia correlates with a prevalence of negative over positive symptoms. The framework of the research is phenomenologically oriented conception of the illness-coping vulnerability paradigm.
Giovanni, Stanghellini, RICCA, VALDO
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Recent advances in the phencyclidine model of schizophrenia.
American Journal of Psychiatry, 1991OBJECTIVE Phencyclidine (PCP, "angel dust") induces a psychotomimetic state that closely resembles schizophrenia. As opposed to amphetamine-induced psychosis, PCP-induced psychosis incorporates both positive (e.g., hallucinations, paranoia) and negative (
D. Javitt, S. Zukin
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