Results 281 to 290 of about 821,521 (329)

Clinically Significant Neuroimaging Findings Among Pediatric Patients Presenting to the Emergency Department With Symptoms of Psychosis: A Multicenter Retrospective Study

open access: yesAcademic Emergency Medicine, EarlyView.
ABSTRACT Background The clinical utility of diagnostic neuroimaging for pediatric patients presenting to the emergency department (ED) for psychosis remains unclear. We sought to estimate the prevalence of and characteristics associated with clinically significant neuroimaging findings among pediatric patients presenting to the ED with symptoms of ...
Jennifer A. Hoffmann   +41 more
wiley   +1 more source

Evaluation of glycine treatment for reducing alcohol craving and self‐administration in individuals with alcohol use disorder: A human laboratory trial

open access: yesAlcohol, Clinical and Experimental Research, EarlyView.
This RCT evaluated whether the glycine receptor (GlyR) agonist glycine reduces craving and alcohol intake in individuals with AUD. Despite a preclinical rationale for targeting the GlyR, these parameters were not reduced. Interestingly, glycine weakened the link between alcohol‐induced craving and self‐administration, and baseline glycine levels were ...
Yasmin Olsson   +3 more
wiley   +1 more source

Cognitive deficits in individuals with comorbid personality disorder and schizophrenia: A scoping review. [PDF]

open access: yesSchizophr Res Cogn
Chalut A   +6 more
europepmc   +1 more source

Regional cerebellum volume anomalies and associated cognitive function in children with fetal alcohol spectrum disorders

open access: yesAlcohol, Clinical and Experimental Research, EarlyView.
Prenatal alcohol exposure (PAE) significantly impacts cerebellum development, which may affect cognitive function in fetal alcohol spectrum disorders (FASD). Using an advanced MRI volumetric method that characterizes detailed cerebellum structure, this study identified regional cerebellum volume anomalies in children with FASD age 8–17 years ...
Blake A. Gimbel   +9 more
wiley   +1 more source

Effects of cannabidiol in alcohol use disorder patients with and without co‐occurring post‐traumatic stress disorder: Tolerability but no evidence for efficacy in two randomized proof‐of‐concept trials

open access: yesAlcohol, Clinical and Experimental Research, EarlyView.
Two small placebo‐controlled trials evaluated the effects of cannabidiol (CBD) in patients with alcohol use disorder (AUD), with and without co‐occurring post‐traumatic stress disorder (PTSD). CBD was rapidly absorbed and generally well tolerated in dosages of up to 1200 mg/day. Both treatment groups showed large reductions in drinking.
Michael P. Bogenschutz   +6 more
wiley   +1 more source

Changed expression of placental transporters and disrupted epigenetic patterns in a rat model of schizophrenia. [PDF]

open access: yesFront Pharmacol
Szatmári P   +5 more
europepmc   +1 more source

Formulating Cognitive Functioning to Guide Personalised Treatment for People Diagnosed With Mental Disorders

open access: yesActa Psychiatrica Scandinavica, EarlyView.
ABSTRACT Introduction Objective and subjective cognitive impairment are highly prevalent in mental disorders and transdiagnostic phenomena. Cognitive impairment is associated with poorer functional outcomes and therefore requires treatment, but little guidance is available for clinicians.
Kelly Allott   +5 more
wiley   +1 more source

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