Results 131 to 140 of about 74,140 (300)

Sulfide-quinone oxidoreductase is required for cysteine synthesis and indispensable to mitochondrial health

Redox Biology, 2021
Mitochondrial dysfunction is related to common age-related disorders, including neurodegenerative diseases, metabolic syndrome, and carcinogenesis. Therefore, maintaining the functionality and integrity of mitochondria is important for human health ...
Xi Zhang, Yuping Xin, Zhigang Chen, Yongzhen Xia, Luying Xun, Huaiwei Liu   +5 more
doaj  

Π-cyc: A Reference-free SNP Discovery Application using Parallel Graph Search [PDF]

arXiv, 2018
Motivation: Working with a large number of genomes simultaneously is of great interest in genetic population and comparative genomics research. Bubbles discovery in multi-genomes coloured de bruijn graph for de novo genome assembly is a problem that can be translated to cycles enumeration in graph theory.
arxiv  

Altering the stability of the Cdc8 overlap region modulates the ability of this tropomyosin to bind cooperatively to actin and regulate myosin. [PDF]

, 2011
Tropomyosin (Tm) is an evolutionarily conserved ?-helical coiled-coil protein, dimers of which form end-to-end polymers capable of associating with and stabilising actin-filaments and regulate myosin function. The fission yeast, Schizosaccharomyces pombe,
East, Daniel A., Edwards, Thomas A., Lehman, William, Martin, Stephen R., Mulvihill, Daniel P., Sousa, Duncan   +5 more
core   +3 more sources

Physiological features of Schizosaccharomyces pombe of interest in making of white wines

European Food Research and Technology, 2012
This work studies the physiology of Schizosaccharomyces pombe strain 938 in the production of white wine with high malic acid levels as the sole fermentative yeast, as well as in mixed and sequential fermentations with Saccharomyces cerevisiaeCru Blanc ...
S. Benito, F. Palomero, A. Morata, F. Calderón, D. Palmero, J. Suárez-Lepe   +5 more
semanticscholar   +1 more source

Novel TORC1 inhibitor Ecl1 is regulated by phosphorylation in fission yeast

Aging Cell, Volume 24, Issue 4, April 2025.
Extender of chronological lifespan 1 (Ecl1), which inhibits the target of rapamycin complex 1 (TORC1), physically interacts with TORC1 subunits and is necessary for appropriate cellular responses to various stressors, such as starvation, in fission yeast. Several functions of Ecl1 are suppressed by Thr7 phosphorylation when nutrients are abundant.
Hokuto Ohtsuka, Sawa Kawai, Yurika Ito, Yuka Kato, Takafumi Shimasaki, Kazuki Imada, Yoko Otsubo, Akira Yamashita, Emi Mishiro‐Sato, Keiko Kuwata, Hirofumi Aiba   +10 more
wiley   +1 more source

Deletion mutants in COP9/Signalosome subunits in fission yeast Schizosaccharomyces pombe display distinct phenotypes [PDF]

, 2001
The COP9/signalosome complex is highly conserved in evolution and possesses significant structural similarity to the 19S regulatory lid complex of the proteasome. It also shares limited similarity to the translation initiation factor eIF3.
Carr, Antony, Liu, C., Mundt, K. E.
core   +3 more sources

Engineering of nicotianamine synthesis enhances cadmium mobility in plants and results in higher seed cadmium concentrations

The Plant Journal, Volume 122, Issue 2, April 2025.
SUMMARY Efficient biofortification, i.e., the enrichment of edible plant organs with micronutrients available for human consumption, is pursued through breeding and genetic engineering approaches. Enriching for iron (Fe) and zinc (Zn), two of the most critical trace elements, in cereal grains can be achieved by boosting the synthesis of nicotianamine ...
Fabian Hollmann, Michael Weber, Mark G. M. Aarts, Stephan Clemens   +3 more
wiley   +1 more source

Checkpoints are blind to replication restart and recombination intermediates that result in gross chromosomal rearrangements [PDF]

, 2015
Replication fork inactivation can be overcome by homologous recombination, but this can cause gross chromosomal rearrangements that subsequently missegregate at mitosis, driving further chromosome instability.
A Janssen, A Letessier, AT Watson, AT Watson, BJ Brewer, C Lukas, D Branzei, E Ampatzidou, E Tsang, EK Schwartz, HD Lindsay, I Miyabe, J Bartkova, J Matos, JA Harrigan, JM Murray, K Mizuno, K Mizuno, K Tanaka, KL Chan, KL Chan, LJ Gaskell, MN Boddy, NC Walworth, O Limbo, P Huertas, PM Dehe, RA Burrell, S Lambert, S Lambert, S Minocherhomji, S Sarbajna, S Ying, SC Ip, SG Durkin, SM Mirkin, T Caspari, V Naim, VG Gorgoulis, X Li   +39 more
core   +1 more source

The extent of error-prone replication-restart by homologous recombination is controlled by Exo1 and checkpoint proteins [PDF]

, 2014
Genetic instability, a hallmark of cancer, can occur when the replication machinery encounters a barrier. The intra-S phase checkpoint maintains stalled replication forks in a replication-competent configuration by phosphorylating replisome components ...
Ahn, Alabert, Bailis, Barlow, Bastia, Bester, Biswas, Boddy, Bolderson, Brown, Bähler, Carr, Carr, Casper, Cha, Chen, Cobb, Cobb, Codlin, Cotta-Ramusino, Dalgaard, De Piccoli, Durkin, El-Shemerly, Errico, Eydmann, Froget, Haghnazari, Halazonetis, Hartsuiker, Heichinger, Hu, Iraqui, Jia, Kai, Kaochar, Katou, Kolodner, Koundrioukoff, Krejci, Lambert, Lambert, Lambert, Lambert, Lambert, Lambert, Lee, Lindsay, Lisby, Lopes, Lucca, Maundrell, Meister, Mimitou, Miyabe, Miyabe, Mizuno, Mizuno, Moreau, Moreau, Moreno, Morin, Myung, Myung, Pandita, Raynard, Sabatinos, Segurado, Segurado, Smolka, Sogo, Stracker, Sun, Symington, Sørensen, Tercero, Tsubouchi, Watson, Zhu, Zou, Zubko   +80 more
core   +2 more sources

Comparative whole genome sequencing reveals phenotypic tRNA gene duplication in spontaneous Schizosaccharomyces pombe La mutants

Nucleic Acids Research, 2011
We used a genetic screen based on tRNA-mediated suppression (TMS) in a Schizosaccharomyces pombe La protein (Sla1p) mutant. Suppressor pre-tRNASerUCA-C47:6U with a debilitating substitution in its variable arm fails to produce tRNA in a sla1-rrm mutant ...
Julien Walzberg, Jean-Marc Frayret, Annika L. Eberle, A. Carpenter, Garvin Heath, Julian Kirchherr, Andrea Urbinati, Kris Hartley, B. M. Xicotencatl, René Kleijn, Sander van Nielen, François Donati, Benjamin Sprecher, A. Tukker, Rajesh Mehta, M. Golkaram, J. Vogels, T. Ligthart, Eugene Someren, Špela Ferjan, Jelmer Lennartz, J. Dunn, Kabian Ritter, J. M. Velázquez, A. Kendall, Joris Šimaitis, Stephen Allen, Christopher Vagg, Francisco Orlando Rosales, B. Fath, Grace Yolanda Llerena, Christoph Stallkamp, Malte Hennig, Rebekka Volk, Frank Richter, Britta Bergfeldt, S. Tavakkol, Frank Schult-mann, Dieter Stapf, Alexander Cimprich, Steven B. Young, Philip Nuss, Esther Sanyé-Mengual, S. Sala, Ceri Fenwick, Kieren Mayers, Jacquetta Lee, Richard Murphy, A. Papangelou, Jean-Baptiste Bahers, L. Aissani, Virginie Litaudon, Yiran Chen   +52 more
semanticscholar   +1 more source